{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:43:39Z","timestamp":1790660619709,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Importance<\/jats:title>\n                    <jats:p>Dietary interventions, vitamins, and nutritional supplementation are playing an increasingly important role in the management of neuropathic pain. Current pharmacological treatments are poorly tolerated and ineffective in many cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review aims to study the efficacy of dietary interventions, vitamins, and nutritional supplementation in the management of chronic neuropathic pain in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Review<\/jats:title>\n                    <jats:p>\n                      The review followed PRISMA guidelines and was registered with PROSPERO (#CRD42022300312). Ten databases and gray literature, including\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/embase.com\">Embase.com<\/jats:ext-link>\n                      , MEDLINE and Web of Science, were systematically searched using a combination of keywords and controlled vocabulary related to chronic neuropathic pain and oral non\u2010pharmacological supplements. Studies on adult humans published between 2000 and 2021 were considered for inclusion. The Cochrane Handbook was used to assess risk of bias, and Grading of Recommendations Assessment, Development, and Evaluation was used to determine overall quality of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Forty studies were included in the final review, and results were categorized according to pain type including pain related to chemotherapy\u2010induced peripheral neuropathy (CIPN, 22 studies, including 3 prospective cohorts), diabetic peripheral neuropathy (DPN, 13 studies, including 2 prospective), complex regional pain syndrome (CRPS\u2010I, 3 studies, including 1 prospective), and other (2 studies, both RCT). The CIPN studies used various interventions including goshajinkigan (4 studies), vitamin E (5), vitamin B12 (3), glutamine (3), N\u2010acetyl\u2010cysteine (2), acetyl\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010carnitine (2), guilongtonluofang (1), ninjin'yoeito (1), alpha\u2010lipoic acid (1),\n                      <jats:sc>l<\/jats:sc>\n                      \u2010carnosine (1), magnesium and calcium (1), crocin (1), and antioxidants (1), with some studies involving multiple interventions. All CIPN studies involved varying cancers and\/or chemotherapies, advising caution for generalizability of results. Interventions for DPN included alpha\u2010lipoic acid (5 studies), vitamin B12 (3), acetyl\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010carnitine (3), vitamin E (1), vitamin D (2), and a low\u2010fat plant\u2010based diet (1). Vitamin C was studied to treat CRPS\u2010I (3 studies, including 1 prospective). Magnesium (1) and St. John's wort (1) were studied for other or mixed neuropathologies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Based on the review, we cannot recommend any supplement use for the management of CIPN, although further research into N\u2010acetyl\u2010cysteine,\n                      <jats:sc>l<\/jats:sc>\n                      \u2010carnosine, crocin, and magnesium is warranted. Acetyl\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010carnitine was found to be likely ineffective or harmful. Alpha\u2010lipoic acid was not found effective. Studies with goshajinkigan, vitamin B12, vitamin E, and glutamine had conflicting results regarding efficacy, with one goshajinkigan study finding it harmful. Guilongtonluofang, ninjin'yoeito, and antioxidants showed various degrees of potential effectiveness. Regarding DPN, our review supports the use of alpha\u2010lipoic acid, acetyl\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010carnitine, and vitamin D. The early use of vitamin C prophylaxis for the development of CRPS\u2010I also seems promising. Further research is warranted to confirm these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.13291","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T02:29:52Z","timestamp":1693535392000},"page":"186-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of diet and non\u2010pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-0591","authenticated-orcid":false,"given":"Jennifer K.","family":"Frediani","sequence":"first","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim A.","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kim","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine  Suwanee Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-977X","authenticated-orcid":false,"given":"Sharon L.","family":"Leslie","sequence":"additional","affiliation":[{"name":"Woodruff Health Sciences Center Library Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-8692","authenticated-orcid":false,"given":"David W.","family":"Boorman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-1401","authenticated-orcid":false,"given":"Vinita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000282763.29778.59"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.11.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092510"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12601"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00095"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1216"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00190.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2021.1260"},{"key":"e_1_2_8_12_1","volume-title":"Covidence systematic review software","year":"2023"},{"key":"e_1_2_8_13_1","unstructured":"HigginsJPT Savovi\u0107J PageMJ ElbersRG SterneJAC.Chapter 8: Assessing risk of bias in a randomized trial.2022. 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