{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:50:17Z","timestamp":1779915017630,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>There is no consensus on which \u201cstrong\u201d (or step 3 WHO analgesic ladder) opioid to prescribe to a particular patient with cancer\u2010related pain. A better understanding of opioid and patient characteristics on treatment response will contribute to a more personalized opioid treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Assessment of potential predictors for successful opioid treatment response in patients with cancer pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international partnership between four cancer pain research groups resulted in a combined individual\u2010level database from four relevant randomized controlled trials (RCTs; <jats:italic>n<\/jats:italic>\u2009=\u2009881). Together, these RCTs investigated the short\u2010term (1\u2009week) and medium\u2010term (4 or 5\u2009weeks) treatment responses for morphine, buprenorphine, methadone, oxycodone, and fentanyl. Candidate predictors for treatment response were sex, age, pain type, pain duration, depression, anxiety, Karnofsky performance score, opioid type, and use of anti\u2010neuropathic drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Opioid type and pain type were found statistically significant predictors of short\u2010term treatment success. Sex, age, pain type, anxiety, and opioid type were statistically, significantly associated with medium\u2010term treatment success. However, these models showed low discriminative power.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fentanyl and methadone, and mixed pain were found to be statistically significant predictors of treatment success in patients with cancer\u2010related pain. With the predictors currently assessed our data did not allow for the creation of a clinical prediction model with good discriminative power. Additional \u2013 unrevealed \u2013 predictors are necessary to develop a future prediction model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13292","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T07:59:47Z","timestamp":1693468787000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Finding predictors for successful opioid response in cancer patients: An analysis of data from four randomized controlled trials"],"prefix":"10.1111","volume":"24","author":[{"given":"Maike S.","family":"Imkamp","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Maastricht University Medical Centre+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-406X","authenticated-orcid":false,"given":"Maurice","family":"Theunissen","sequence":"additional","affiliation":[{"name":"Center of Expertise for Palliative Care Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-729X","authenticated-orcid":false,"given":"Sander M.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Maastricht University Medical Centre+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Haumann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Management OLVG  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Corli","sequence":"additional","affiliation":[{"name":"Department of Oncology Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bosetti","sequence":"additional","affiliation":[{"name":"Department of Oncology Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Leppert","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Institute of Medical Sciences University of Zielona G\u00f3ra  Zielona G\u00f3ra Poland"},{"name":"University Hospital of Heliodor \u015awi\u0119cicki  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Pain Therapy and Rehabilitation Unit Fondazione IRCCS Istituto Nazionale Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Zecca","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Pain Therapy and Rehabilitation Unit Fondazione IRCCS Istituto Nazionale Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-2862","authenticated-orcid":false,"given":"Marieke H.","family":"van den Beuken\u2010van\u00a0Everdingen","sequence":"additional","affiliation":[{"name":"Center of Expertise for Palliative Care Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","article-title":"Opioids for cancer pain \u2013 an overview of cochrane reviews","author":"Wiffen PJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70040-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw097"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2008\/11\/S133"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.03.04"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2018.0281"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S141007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190717091230"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.05.030"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.01.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3944"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0697"},{"issue":"5","key":"e_1_2_9_16_1","article-title":"Morphine for chronic neuropathic pain in adults","author":"Cooper TE","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_17_1","volume-title":"WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents","author":"World Health Organization","year":"2018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2021.07.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12036"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909109341868"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2012.0141"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2007.0005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104447"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2149"},{"key":"e_1_2_9_26_1","first-page":"1423","article-title":"Pain polymorphisms and opioids: an evidence based review","volume":"19","author":"Vieira CMP","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12757"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T05:09:21Z","timestamp":1705554561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.13292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/papr.13292"],"URL":"https:\/\/doi.org\/10.1111\/papr.13292","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]},"assertion":[{"value":"2023-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}