{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:20:20Z","timestamp":1776928820206,"version":"3.51.2"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic low back pain is associated with both psychological and functional limitation. Yoga therapy has been shown to improve both the aspects. The present study was planned to evaluate integrated approach of yoga therapy with usaul care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This controlled randomized trial was done to evaluate the clinical and molecular changes resulting from integrated approach of yoga therapy (IAYT) as an adjunct regimen and compared it with usual care for the management of chronic low back pain patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We enrolled 29 adult patients with non\u2010specific chronic low back pain (CLBP). Patients were randomly divided into two groups. The control group received the usual care of treatment as per institutional protocol. The yoga group received IAYT as an adjunct to usual care. Primary outcomes were pain intensity assessed by verbal numerical rating scale (VNRS) and functional ability assessed by Modified Oswestry Disability Index (MODI). Secondary outcomes were pain catastrophizing, quality of life, fear of movement related to CLBP, type of pain, levels of \u03b2\u2010endorphin and TNF\u2010\u03b1, and salivary CGRP. All parameters were measured at baseline, 1 and 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A Significant decrease in VNRS score at 1 and 3\u2009months was observed in both the groups with the yoga group showing a more significant reduction in pain over time than the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.036). MODI improved significantly only in the yoga group at 1 and 3\u2009months. Intergroup comparison revealed significantly better MODI over time in the yoga group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). DN4, PDQ, PCS, HADS (anxiety), and Euro QOL had a statistically significant improvement at 1 and 3\u2009months in the yoga group compared with the control group. The HADS (depression) had a statistically significant reduction scores in the yoga group at 3\u2009months compared with the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). There was a significant reduction in TNF\u2010\u03b1 values in the yoga group compared with baseline (<jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IAYT therapy helped in addressing the psychological components of pain and improved quality of life patients with chronic low back pain compared with usual care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13296","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T11:59:26Z","timestamp":1695124766000},"page":"248-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of integrated approach of yoga therapy versus usual care in management on chronic low back pain patients: A randomized controlled pilot study"],"prefix":"10.1111","volume":"24","author":[{"given":"Spoorthi","family":"Poojari","sequence":"first","affiliation":[{"name":"Neuroscience 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