{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:49:13Z","timestamp":1790754553423,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The impact of benzodiazepine use on mortality in patients with chronic non\u2010cancer pain (CNCP) has not been identified. We aimed to examine the factors associated with benzodiazepine use among patients with CNCP and examine whether long\u2010term benzodiazepine usage is associated with mortality in patients with CNCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted using data from the National Health Insurance Service database of South Korea. We selected 2.5% of all adult patients diagnosed with musculoskeletal diseases (MSD) in South Korea from 2010 to 2019 using a stratified random sampling technique and included them in the analysis as patients with CNCP. The risk of 10\u2010year all\u2010cause mortality in patients with CNCP was investigated using the 2010 cohort of patients with CNCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of the study population that used benzodiazepine during the 10\u2010year study period was 2.1% (390,683\/18,770,234). Multivariable logistic regression showed that old age; increased Charlson comorbidity index (CCI); opioid, gabapentin or pregabalin, paracetamol, non\u2010steroidal anti\u2010inflammatory drugs, and Z\u2010drugs usage; and underlying psychiatric comorbidities were associated with increased benzodiazepine use. In addition, benzodiazepine use was associated with increased 10\u2010year all\u2010cause mortality (adjusted hazard ratio: 1.03, 95% confidence interval: 1.01, 1.06; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Benzodiazepine was prescribed to 2.1% of the patients with CNCP in South Korea from 2010 to 2019. Old age, increased CCI, underlying psychiatric comorbidities, and use of certain drugs are associated with increased use of benzodiazepines. In addition, benzodiazepine use is associated with 10\u2010year all\u2010cause mortality in patients with CNCP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13312","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:52:10Z","timestamp":1698130330000},"page":"409-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term benzodiazepine usage and mortality in patients with chronic non\u2010cancer musculoskeletal pain: A Nationwide cohort study"],"prefix":"10.1111","volume":"24","author":[{"given":"Tak Kyu","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine Seoul National University  Seoul South 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