{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:29:56Z","timestamp":1751448596421,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1G1A1011055"],"award-info":[{"award-number":["NRF\u20102019R1G1A1011055"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic opioid use is associated with problematic opioid use, such as opioid abuse. It is important to develop a prediction model for safe opioid use. In this study, we aimed to develop and validate a risk score model for chronic opioid use in opioid\u2010na\u00efve, noncancer patients, using data from a nationwide database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the National Health Insurance Claims Database in the Republic of Korea from 2016 to 2018 were used, and adult, noncancer patients who were started on non\u2010injectable opioid analgesics (NIOAs) were included. The risk score model was developed using the \u03b2 coefficient of each variable in the multivariable logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 676,676 noncancer patients were started on NIOAs, of which 65,877 (9.7%) were prescribed NIOAs chronically. Age, baseline healthcare utilization, comorbidities, co\u2010medications, and pattern of first NIOA prescription were identified as risk factors for chronic opioid use. The c\u2010static for the performance of our risk score model was 0.754 (95% confidence interval, 0.750\u20130.758).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first tool that can predict chronic opioid use in the Korean population. The model can help physicians examine the risk of chronic opioid use by patients who are started on NIOA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13320","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:17:03Z","timestamp":1700565423000},"page":"458-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and validation of a predictive model for persistent opioid use in new opioid analgesic users via a nationwide claims database"],"prefix":"10.1111","volume":"24","author":[{"given":"Yoojin","family":"Noh","sequence":"first","affiliation":[{"name":"Pharmacy School Massachusetts College of Pharmacy and Health Sciences University  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-3999","authenticated-orcid":false,"given":"Kyu\u2010Nam","family":"Heo","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Bean","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yeungnam University  Gyeongsan Gyeongbuk Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-7330","authenticated-orcid":false,"given":"Ju\u2010Yeun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-9828","authenticated-orcid":false,"given":"Young\u2010Mi","family":"Ah","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yeungnam University  Gyeongsan Gyeongbuk Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012509.pub2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.11m01326"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/m14\u20102559"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2011.05.110030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7006a4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101558"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/m19\u20103600"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2018.06.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001242"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0504"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.4514"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250972"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.08.012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/eja.0000000000001528"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih\/e2014008"},{"key":"e_1_2_10_17_1","unstructured":"TRIPOD.Checklist for Prediction Model Validation. 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