{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:08:22Z","timestamp":1784333302044,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stiff person syndrome (SPS) is a rare neuroimmunological disorder characterized by rigidity and painful spasm primarily affecting the truncal and paraspinal musculature due to autoimmune\u2010mediated neuronal hyperexcitability. Spinal cord stimulation (SCS) is an approved therapy for managing painful neuropathic conditions, including diabetic peripheral neuropathy and refractory angina pectoris. We describe the novel use of SCS for the treatment of spasm and rigidity in a 49\u2010year\u2010old man with seropositive stiff person syndrome (SPS). The patient was treated with intravenous immunoglobulin (IVIG) and oral medications over a 13\u2010month period with minimal improvement, prompting consideration of SCS. To our knowledge, this is the first report of the successful use of SCS in SPS with the demonstration of multifaceted clinical improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following a successful temporary SCS trial, permanent implantation was performed. Spasm\/stiffness (Distribution of Stiffness Index; Heightened Sensitivity Scale; Penn Spasm Frequency Scale, PSFS), disability (Oswestry Disability Index, ODI; Pain Disability Index, PDI), depression (Patient Health Questionnaire\u20109, PHQ\u20109), sleep (Pittsburgh Sleep Quality Index, PSQI), fatigue (Fatigue Severity Scale, FSS), pain (Numerical Pain Rating Scale, NPRS), quality of life (EuroQoL 5 Dimension 5 Level, EQ\u20105D\u20105L), and medication usage were assessed at baseline, 6\u2010month, and 10\u2010month postimplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ODI, PHQ\u20109, FSS, NPRS, PSQI, and EQ\u20105D\u20105L scores showed a notable change from baseline and surpassed the defined minimal clinically important difference (MCID) at 6\u2010month and 10\u2010month follow\u2010up. Oral medication dosages were reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel use of SCS therapy in seropositive SPS resulted in functional improvement and attenuation of symptoms. We present possible mechanisms by which SCS may produce clinical response in patients with SPS and aim to demonstrate proof\u2010of\u2010concept for a future comprehensive pilot study evaluating SCS\u2010mediated response in SPS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13340","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T04:29:35Z","timestamp":1704688175000},"page":"798-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spinal cord stimulation for the symptomatic treatment of rigidity and painful spasm in a case of stiff person syndrome"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2418-7304","authenticated-orcid":false,"given":"Janus","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina 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