{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:32:40Z","timestamp":1771050760471,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Epidural steroid injections (ESIs) are commonly used as a treatment for lumbar radiculopathy. Currently, most research on comparative efficacy of various steroids in epidural steroid injections is focused on transforaminal ESIs (TFESIs). Through this study, we aimed to compare various steroid doses with or without local anesthetic in interlaminar ESIs (ILESIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed charts for all adult patients who received ILESIs identified by CPT code 62323 between January 2017 to April 2021. Baseline demographic data including age, sex, BMI, and smoking status were recorded. NRS pain scores before the injection and percentage of pain relief at 1\u2010month follow\u2010up were recorded. We compared percentage of patients reporting pain relief at 1\u2009month follow\u2010up of low\u2010dose dexamethasone alone (5\u2009mg), to low\u2010dose dexamethasone mixed with local anesthetic, and to high\u2010dose dexamethasone (10\u2009mg) mixed with local anesthetic, specifically for ILESIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available for 311 patients. There was no significant difference in pain relief between the 3 groups at 1\u2009month follow\u2010up. The majority of patients had moderate to significant improvement in pain, supporting the use of ILESIs. Moreover, low\u2010dose steroid with local anesthetic was found to be as efficacious as high\u2010dose steroid alone. Although not statistically significant, the addition of local anesthetic to low\u2010dose or high\u2010dose steroid increased the percentage of patients reporting moderate to significant pain relief.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ILESIs with non\u2010particulate steroids provide moderate to significant pain improvement in the short term, with low\u2010dose steroid mixed with local anesthetic being as efficacious as a high\u2010dose steroid.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13410","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T06:13:52Z","timestamp":1726899232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A comparison of steroid dose with or without local anesthetic in lumbar interlaminar epidural steroid injections"],"prefix":"10.1111","volume":"25","author":[{"given":"Robert","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5703-8698","authenticated-orcid":false,"given":"Jessica","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Yanez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2988-4590","authenticated-orcid":false,"given":"Zili","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanishka","family":"Rajput","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yale University School of Medicine  New Haven Connecticut 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studies for lumbosacral radicular pain","volume":"17","author":"Chang\u2010Chien GC","year":"2014","journal-title":"Pain Physician"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2020.33.3.226"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2016.09.010"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.00932.x"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013042"},{"key":"e_1_2_13_27_1","unstructured":"Medicare.Injection(s) of diagnostic or therapeutic substance(s) (eg anesthetic antispasmodic opioid steroid other solution) not including neurolytic substances including needle or catheter placement interlaminar epidural or subarachnoid lumbar or sacral (caudal); with imaging guidance (ie fluoroscopy or ct).2023; Available 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