{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:42:06Z","timestamp":1776894126316,"version":"3.51.2"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This single\u2010arm, open\u2010label, single\u2010center observational pilot study assessed the safety and efficacy of ultrahigh\u2010frequency dorsal root ganglia (UHF\u2010DRG) stimulation in patients with chronic leg pain with or without low back pain. Such high\u2010frequency electrostimulation had not been conducted in the human central nervous system previously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The primary objective was to evaluate the safety of UHF\u2010DRG stimulation (2\u2009Hz pulses with 50\u2009msec pulse\u2010width and 500\u2009kHz intrapulse sine waves, 5\u2010min duration per stimulation) by identifying incident adverse events (AE) and severe adverse events (SAE) during the trial. The secondary objectives included assessment of pain reduction using a numerical rating score (NRS), presence of paraesthesia, and changes in four pain medications (weak opioids, anticonvulsants, antidepressants, and non\u2010steroid\u2010anti\u2010inflammatory drugs). One DRG lead was implanted for one day then removed, and the patients received maximal three times of UHF stimulation in total.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study focused on ten cases. Two of them did not complete the study due to difficulty of lead implantation. There was no SAE in this trial. Among the ten cases, AEs occurred in eight, three experienced injection\u2010related local pain and one of them had a post\u2010dural\u2010puncture headache, others had symptoms un\u2010related to implantation procedure or UHF stimulation. The average NRS was reduced from 6.4\u2009\u00b1\u20091.1 at baseline to 2.9\u2009\u00b1\u20091.1 on the second\u2010day post\u2010implantation, and it was striking that the NRS was maintained at 3.6\u2009\u00b1\u20092.8 until 2\u2009days after lead removal. The results showed a trend of lower frequency in medication use for all types of analgesics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this first\u2010in\u2010human pilot study, we discovered that intermittent pulsed UHF\u2010DRG stimulations ameliorated chronic lower limb pain for an extended period in humans. Our finding opens up a new neuromodulatory concept and may initiate a novel paradigm for treating intractable pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13436","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:29:22Z","timestamp":1732022962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A pilot study of novel ultrahigh\u2010frequency dorsal root ganglia stimulation for chronic lower limb pain: Focusing on safety and feasibility"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-5069","authenticated-orcid":false,"given":"Shang\u2010Yi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Taichung Veterans General Hospital Puli Branch  Nantou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai\u2010Huan","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Department of Nursing and Graduate Institute of Nursing Asia University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth B.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology New York University Langone Medical Center  New York City New York USA"},{"name":"Department of Anesthesiology Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Kai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh\u2010Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tsaotun Psychiatric Center Ministry of Health and Welfare  Nantou Taiwan"},{"name":"School of Medicine China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuen\u2010Bao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Anesthesiology China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Heng","family":"Chang","sequence":"additional","affiliation":[{"name":"Gimer Medical Co. 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