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However, the application of placebo\u2010based treatment strategies in routine medical care is questioned. The current study investigated the opinions of patients with fibromyalgia and healthy controls regarding learning of placebo effects and their practical applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An online survey asked 158 age\u2010 and sex\u2010matched adult patients and controls (79 per group) to rate the perceived influence of various placebo learning mechanisms on pain relief, and the acceptability and perceived effectiveness of placebo\u2010based strategies (open\u2010label, closed\u2010label, dose\u2010extending, and treatment\u2010enhancing strategies). Respondents' knowledge about placebo effects was obtained through a 7\u2010item quiz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups did not differ in the perceived influence of placebo learning mechanisms on pain relief (<jats:italic>p<\/jats:italic>\u2009=\u20090.217). Controls considered closed\u2010label and treatment\u2010enhancing strategies more acceptable than patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.003 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas controls perceived all strategies more effective. In both groups, closed\u2010label strategies were significantly less acceptable than any other strategy (<jats:italic>p<\/jats:italic>\u2010values\u2009&lt;\u20090.001), and treatment\u2010enhancing or dose\u2010extending strategies were most acceptable. Higher acceptability was predicted by higher perceived effectiveness ratings (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Also, increased placebo knowledge was related to higher acceptability (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and perceived effectiveness (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This survey suggests that both the medical history of patients and knowledge about placebo effects affect the acceptability and perceived effectiveness of placebo\u2010based strategies. Furthermore, strategies that are transparent, assumed effective, or combined with existing medical treatments are deemed most acceptable. Keeping these factors in mind is essential for the clinical implementation of placebo\u2010based strategies in routine medical care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.70000","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T08:51:36Z","timestamp":1737967896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do patients with fibromyalgia syndrome and healthy people differ in their opinions on placebo effects in routine medical care?"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1596-094X","authenticated-orcid":false,"given":"Johan P. 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