{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:36:35Z","timestamp":1787646995365,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of closed\u2010loop spinal cord stimulation (CL\u2010SCS) and dorsal root ganglion (DRG) stimulation in managing chronic cancer\u2010related pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material\/Methods<\/jats:title><jats:p>A retrospective review was conducted with IRB exemption for four patients with cancer\u2010related pain who underwent combination stimulator trials. Patients were trialed with both CL\u2010SCS and DRG stimulation for 8\u201310\u2009days, with assessments of pain relief, functional improvement, sleep improvement, pain medication changes, and overall satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All four patients reported significant relief and functional improvement with both CL\u2010SCS and DRG stimulations. CL\u2010SCS provided a range of 12.9\u201319.6 million adjustments during the trial period. Neural dose was delivered at a median dose ratio of 1.35 and median dose accuracy of 4.9\u2009\u03bcV. Patients 1\u20133 preferred CL\u2010SCS for paresthesia\u2010based stimulation, having the potential to expand pain coverage, full\u2010body MRI compatibility, and real\u2010time automated adjustment features. Patient 4 favored DRG for its ability to provide slightly greater relief, over one aspect of his pain area, despite having comparable coverage with CL\u2010SCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The consistent and adaptable delivery of CL\u2010SCS may bridge the gap in efficacy that DRG therapy has held over traditional dorsal column stimulation for historically complex and focal conditions that suggests further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.70010","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T05:09:57Z","timestamp":1737349797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative efficacy of closed\u2010loop spinal cord stimulation and dorsal root ganglion stimulation through combination trialing for cancer pain \u2013 A retrospective case series"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0931-8643","authenticated-orcid":false,"given":"Matthew","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-7860","authenticated-orcid":false,"given":"Alaa","family":"Abd\u2010Elsayed","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.5206"},{"key":"e_1_2_10_3_1","volume-title":"Cancer Facts & Figures\u00a02020","author":"American Cancer Society","year":"2020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12634"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102023\u2010104751"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010022\u201002244\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000814"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12072"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12228"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102018\u2010000007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S364370"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081909"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13361"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:07:57Z","timestamp":1754914077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/papr.70010"],"URL":"https:\/\/doi.org\/10.1111\/papr.70010","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"2025-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70010"}}