{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:53:14Z","timestamp":1776775994419,"version":"3.51.2"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Thoracic epidural analgesia has traditionally been used for pain management after open abdominal surgery, but its use has declined. The quest for efficient alternatives has resulted in the increasing use of regional techniques. These can be applied as single\u2010shot or continuous blocks using catheters. Long\u2010acting liposomal bupivacaine could preclude the use of catheters. This review aimed to evaluate the effectiveness of ultrasound\u2010guided abdominal wall blocks with liposomal bupivacaine for open abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Databases and Data Treatment<\/jats:title><jats:p>Medline ALL, Embase, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Google Scholar were systematically searched. Screening, data extraction, and quality assessment were done by two independent researchers. Inclusion criteria were (1) liposomal bupivacaine in ultrasound\u2010guided abdominal wall blocks for open abdominal surgery, (2) outcome of pain and\/or opioid consumption, (3) patients &gt;18\u2009years, and (4) reports published in English.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1277 studies found, 22 met the inclusion criteria. The Cochrane Risk of Bias (Version 2) tool was used to assess randomized controlled trials. Studies were grouped for clarity. Transversus abdominis plane (TAP) blocks were mostly investigated. Data were heterogenic regarding types of surgery, approach to block placement, anesthetic solution injected, and use of intrathecal morphine (ITM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients undergoing cesarean section with neuraxial anesthesia and intrathecal morphine benefit from TAP blocks with liposomal bupivacaine, demonstrating reduced opioid consumption and comparable pain. Evidence for other open abdominal surgeries was inconclusive. Abdominal wall blocks with liposomal bupivacaine could be a viable alternative when epidural analgesia is contraindicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.70016","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T12:33:21Z","timestamp":1739968401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effectiveness of liposomal bupivacaine in ultrasound\u2010guided abdominal wall blocks after open abdominal surgery: A systematic review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3366-2368","authenticated-orcid":false,"given":"Maya S.","family":"Vereen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent J.","family":"Bidault","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Krabbendam","sequence":"additional","affiliation":[{"name":"Medical Library Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne E.","family":"Hoeks","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Jan","family":"Stolker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike","family":"Dirckx","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2002.11927867"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkt062"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/eja.0000000000000319"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2018.07.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31817e7065"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/aap.0000000000000545"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/eja.0000000000001600"},{"key":"e_1_2_12_9_1","unstructured":"UpToDate.2024. Uptodate.com.https:\/\/www.uptodate.com\/contents\/abdominal\u2010nerve\u2010block\u2010techniques?search=abdominal%20wall%20blocks&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1(last accessed 18 January 2024)."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010018\u20101705\u2010y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8284363"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S132891"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s27894"},{"key":"e_1_2_12_14_1","unstructured":"Topics\u2014NYSORA. NYSORA.https:\/\/www.nysora.com\/filter\u2010topics\/?_sft_category=truncal\u2010and\u2010cutaneous\u2010blocks(last accessed 18 January 2024)."},{"key":"e_1_2_12_15_1","unstructured":"EMA.Exparel liposomal\u2014European Medicines Agency. European Medicines Agency.2020.https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/exparel\u2010liposomal(last accessed 18 January 2024)."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000003651"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.596653"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000004932"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2021.962"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2018.283"},{"key":"e_1_2_12_22_1","unstructured":"HarzingAW.Publish or Perish.2016. Harzing.com. Published February 6 2016.https:\/\/harzing.com\/resources\/publish\u2010or\u2010perish(last accessed 24 January 2024)."},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2017.183"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3163\/1536\u20105050.104.3.014"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2017.111"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110527"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000005075"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010020\u201001911\u20101"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010021\u201009622\u20107"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110640"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s184279"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/17455065211058046"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2022.2090798"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26711"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2018.03.003"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13581"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153675"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/dcr.0000000000000747"},{"key":"e_1_2_12_41_1","article-title":"The use of exparel in transversus abdominus plane blocks for postoperative pain control","volume":"360","author":"Dammann K","year":"2020","journal-title":"J Pain Relief"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13347"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2024.05.011"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.joacp_358_18"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojanes.2017.712042"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.7205\/milmed\u2010d\u201014\u201000512"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.15406\/jaccoa.2016.06.00214"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48234"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr3.12284"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238634"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-94482-1"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq\u20102023\u2010002313"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20109185.161671"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34142"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14868"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010020\u201001910\u20102"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:24:37Z","timestamp":1741739077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.70016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/papr.70016"],"URL":"https:\/\/doi.org\/10.1111\/papr.70016","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"assertion":[{"value":"2025-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70016"}}