{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:59:54Z","timestamp":1790272794959,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The SpineJack implant system is an FDA\u2010approved treatment modality for vertebral compression fractures (VCFs) with reported clinical efficacy comparable to the gold\u2010standard balloon kyphoplasty. Specifically, there is insufficient literature regarding the treatment and safety outcomes of the SpineJack when analyzing a specific subset of patients such as the cancer population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an institutional\u2010level retrospective study at a cancer center on the SpineJack implant consisting of 67 cancer patients (mean age 64\u2009\u00b1\u200913\u2009years) undergoing a total of 94 SpineJack implantations inserted at 15 thoracolumbar vertebral levels for the treatment of pathologic vertebral compression fractures. The primary outcome of the study was the change in pain score based on the Numeric Rating Scale (NRS) and the secondary outcome was the change in opioid requirement based on morphine milligram equivalents (MME). The average follow\u2010up period was 2\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010procedure, a statistically significant decrease in pain severity was observed, with the mean pain score improving from 7.72\u2009\u00b1\u20092.29 points to 3.45\u2009\u00b1\u20092.55 points (<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.0001). Additionally, a reduction in opioid requirement was noted, with a decrease in MME from 66.42\u2009\u00b1\u200992.66\u2009mg preoperatively to 43.1\u2009\u00b1\u200960.78\u2009mg (<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.0001) postoperatively. There was a 1.5% (<jats:italic>N<\/jats:italic>\u2009=\u20091) incidence of adjacent level fracture (ALF) reported over an average of 2\u2010week follow\u2010up. The most common intraoperative complication reported was cement extravasation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, treatment of cancer patients with pathologic fractures using the SpineJack procedure resulted in remarkably decreased pain scores, overall decreased MME requirements, a significantly low incidence of ALF (s), and minor intraoperative complications without long\u2010term consequences. The SpineJack procedure is a clinically effective, low\u2010risk treatment option for cancer patients with symptomatic, pathologic VCFs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.70020","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T19:55:41Z","timestamp":1741463741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short\u2010term clinical outcomes and safety of the <scp>SpineJack<\/scp> implant system for the treatment of pathological vertebral compression fractures in cancer patients: A retrospective analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4876-8850","authenticated-orcid":false,"given":"Jason","family":"Parmar","sequence":"first","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Physical Medicine and Rehabilitation Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-7084","authenticated-orcid":false,"given":"Aila","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Physical Medicine and Rehabilitation The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelilla","family":"Zemmedhun","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-8904","authenticated-orcid":false,"given":"Saba","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls","author":"Donnally CJ","year":"2024"},{"key":"e_1_2_11_3_1","first-page":"585","article-title":"Pathologic vertebral fractures: diagnosis, treatment, complications, and controversies through case\u2010based learning","volume":"68","author":"Tobert DG","year":"2019","journal-title":"Instr Course Lect"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22991"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"44","article-title":"Diagnosis and Management of Vertebral Compression Fractures","volume":"94","author":"McCarthy J","year":"2016","journal-title":"Am Fam Physician"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2021.04.031"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8031"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2021.10.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2023.1121981"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/173872"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.162"},{"issue":"4","key":"e_1_2_11_12_1","article-title":"Re\u2010expansion of osteoporotic compression fractures using bilateral SpineJack implants: early clinical experience and biomechanical considerations","volume":"11","author":"Jacobson RE","year":"2019","journal-title":"Cureus"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.70020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:24:44Z","timestamp":1741739084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.70020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/papr.70020"],"URL":"https:\/\/doi.org\/10.1111\/papr.70020","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70020"}}