{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:00:48Z","timestamp":1791910848852,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The development of liposomal bupivacaine (LB) as an anesthetic was widely lauded due to the potential benefits this drug claimed to carry. This systematic review and meta\u2010analysis aimed to assess the efficacy of LB versus standard bupivacaine (SB) in improving postoperative outcomes, including pain scores and morphine use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane CENTRAL, Web of Science, and MedLine databases were searched until April 2024. All trials evaluating the efficacy of LB versus SB in abdominal surgeries like colorectal procedures, bariatric surgeries, and hemorrhoidectomy were included. Data analysis was conducted in Review Manager employing a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight clinical trials with 810 patients were included. No statistically or clinically significant result was obtained on using LB over SB in reducing postoperative pain score on postoperative day 0 (POD0) (mean difference (MD)\u2009=\u2009\u22120.19, [95% confidence interval (CI): \u22120.91, 0.53];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.60), POD1 (MD\u2009=\u2009\u22120.11 [95% CI: \u22121.12, 0.91];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.84), POD2 (MD\u2009=\u2009\u22120.18 [95% CI: \u22120.57, 0.22];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.22), and POD3 (MD\u2009=\u20090.01 [95% CI: \u22120.55, 0.22];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.57). Additionally, there was no reduction in morphine use in PODs 0\u20133, time to ambulation, hours to postoperative flatus, or length of hospital stay between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings showed that LB is not superior to SB in the surgical plane for individuals undergoing abdominal procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70048","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:41:57Z","timestamp":1747647717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Liposomal Bupivacaine Versus Standard Bupivacaine Following Abdominal Surgeries: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2713-3233","authenticated-orcid":false,"given":"Mohamed","family":"Saad Sayed","sequence":"first","affiliation":[{"name":"Faculty of Medicine Beni\u2010Suef University  Beni Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4273-0827","authenticated-orcid":false,"given":"Shree","family":"Rath","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-6257","authenticated-orcid":false,"given":"Warda","family":"Rasool","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-9593","authenticated-orcid":false,"given":"Fatima","family":"Saeed","sequence":"additional","affiliation":[{"name":"United Medical and Dental College  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5343-1029","authenticated-orcid":false,"given":"Haider","family":"Kashif","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences  Karachi Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-5433","authenticated-orcid":false,"given":"Mohab","family":"Amer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4952"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.03.031"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002346"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000648"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002008"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481207800540"},{"issue":"7","key":"e_1_2_13_8_1","article-title":"Clinical Efficacy of Liposomal Bupivacaine: A Systematic Review of Prospective, Randomized Controlled Trials in Orthopaedic Surgery","volume":"7","author":"Abildgaard J. T.","year":"2019","journal-title":"Journal of Bone and Joint Surgery \u2013 Reviews"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.01.036"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2018.1487445"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u2010121142"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15377"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004932"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-022-06417-x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s44158\u2010023\u201000129\u2010Z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_13_22_1","unstructured":"\u201cDose Equivalents and Changing Opioids \u201d Faculty of Pain Medicine https:\/\/www.fpm.ac.uk\/opioids\u2010aware\u2010structured\u2010approach\u2010opioid\u2010prescribing\/dose\u2010equivalents\u2010and\u2010changing\u2010opioids."},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002346"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.03.031"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt\u20102021\u20100033"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481908500945"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010023\u201003699\u20104"},{"issue":"3","key":"e_1_2_13_29_1","article-title":"A Randomized Controlled Trial of Liposomal Bupivacaine for Pain Following Obstetrical Laceration","volume":"2","author":"Dengler K. L.","year":"2020","journal-title":"American Journal of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.07.023"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-102427"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151\u2010023\u201002881\u20104"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000007226"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010019\u20102660\u20107"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:47:25Z","timestamp":1749430045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/papr.70048"],"URL":"https:\/\/doi.org\/10.1111\/papr.70048","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70048"}}