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Cluster headache is classified into two forms: episodic and chronic, with chronic cluster headache defined by pain\u2010free intervals of less than 3\u2009months between bouts. Both drug\u2010based and invasive treatments are available for abortive and preventive purposes. Treatment selection depends on individual efficacy and tolerance, with invasive options considered when pharmacological treatments prove ineffective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This narrative review summarizes the literature on common practice and the evidence in the treatment of cluster headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oxygen therapy and subcutaneous sumatriptan are the most effective abortive treatments for cluster headache. Oral corticosteroid tapering regimens can be used as bridging therapy. Verapamil, lithium, topiramate, and CGRP antagonists are potential preventive medication options.<\/jats:p>\n                    <jats:p>Greater occipital nerve (GON) injections and radiofrequency (RF) therapy can be used as preventive treatments, though their effects are often temporary. For refractory chronic cluster headache, occipital nerve stimulation (ONS) has proven to be effective. Deep brain stimulation (DBS) may also be considered if all other treatments have failed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The management of cluster headache is complex due to the variable efficacy of treatments across different patients and limited evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70050","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:44:37Z","timestamp":1748479477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["15. 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