{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:19:34Z","timestamp":1792009174312,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Spinal cord injury (SCI) is a debilitating condition frequently associated with chronic symptoms such as central neuropathic pain (CNP) and its related complications. Gabapentinoids are often used in the treatment of post\u2010SCI CNP; however, the optimal management of this condition is still unclear. This study aimed to assess the efficacy and safety of gabapentinoids compared with placebo in post\u2010SCI patients affected by CNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched PubMed, Embase, and Cochrane Library databases for randomized controlled trials (RCTs) comparing gabapentinoids (gabapentin, pregabalin, or mirogabalin) with placebo in post\u2010SCI patients experiencing CNP. We calculated mean differences (MD) and risk ratios (RR) for continuous and dichotomous outcomes, respectively, with 95% confidence intervals (CI). Pain was measured on a 0 to 10 numerical rating scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 5 RCTs comprising 682 patients. The mean age was 50.2\u2009years, and 83.8% were male. When compared with placebo, patients treated with gabapentinoids experienced a significant decrease in average daily pain (MD \u22121.75; 95% CI: \u22123.23 to \u22120.28; <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and pain\u2010related sleep interference (MD \u22120.99; 95% CI: \u22121.38 to \u22120.60; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Additionally, there were higher proportions of individuals with pain intensity relief \u2265\u200950% (RR 2.19; 95% CI: 1.47 to 3.25; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and with at least some perceived improvement on the clinical global impression scale (RR 1.71; 95% CI: 1.34 to 2.18, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in the gabapentinoids group compared to the placebo group. However, treatment with gabapentinoids was associated with a significantly increased risk of blurred vision (RR 8.55; 95% CI: 1.53 to 47.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.02), somnolence (RR 3.77; 95% CI: 2.44 to 5.84; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), peripheral edema (RR 2.86; 95% CI: 1.37 to 5.99; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and dizziness (RR 2.83; 95% CI: 1.67 to 4.78; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this meta\u2010analysis of RCTs evaluating patients with CNP following SCI, gabapentinoids were associated with significant improvements in pain and pain\u2010related sleep interference compared with placebo. Nonetheless, gabapentinoids significantly increased the risk of adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.70060","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T09:36:35Z","timestamp":1752917795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gabapentinoids for Neuropathic Pain After Spinal Cord Injury: An Updated Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-2090","authenticated-orcid":false,"given":"Rafael Batista","family":"Jo\u00e3o","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurophysiology Goi\u00e2nia Neurological Institute  Goi\u00e2nia GO Brazil"},{"name":"Division of Neurology, Department of Internal Medicine S\u00e3o Vicente de Paulo Charity Hospital  Jundia\u00ed SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilly Octoria","family":"Tagore Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Indonesia  Depok WJ Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewen Shengyao","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genesis Pamela Mora","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Guayaquil  Guayaquil Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u00edbal Valencia","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Universidad Tecnol\u00f3gica de Pereira  Pereira Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Thota","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kamineni Institute of Medical Sciences  Narketpally Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-0932","authenticated-orcid":false,"given":"Julyana Medeiros","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Federal University of Rio Grande Do Norte  Natal RN Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101960"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.20081"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2021.06.022"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.06.019"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2021.07.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13103"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2016.1202764"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463720912496"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.057"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201709"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318281546b"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000112068.16108.3A"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.834815"},{"key":"e_1_2_13_15_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.3","author":"Higgins J.","year":"2022"},{"key":"e_1_2_13_16_1","first-page":"n71","article-title":"Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"2021","author":"Page M. 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