{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:05:39Z","timestamp":1768403139084,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the role of Autologous Fat Transfer (AFT) for secondary occipital neuralgia (SON).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Secondary occipital neuralgia manifests as neuropathic pain developing after traumatic tissue injury. Multidisciplinary management mainly relies on analgesic medications and local anesthetic and steroid infiltrations. Autologous fat transfer restores subcutaneous tissue, mechanically releasing scar from nerve fibers. In this study, we show the therapeutic uses of AFT for secondary, drug\u2010resistant headaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 19 patients with secondary occipital neuralgia associated with occipital scalp scarring were included. All patients presented with symptoms of unremitting greater or lesser occipital neuralgia, which temporarily improved (&gt;\u200950% temporary reduction in pain intensity) following local anesthesia infiltration of the scar. Patients' evaluation of pain by visual analog scale (VAS), number of acute spasmodic pain events and medication intake per month were assessed before and 12\u2009months after AFT. Evolution of tactile detection thresholds and allodynia patches was determined by Weinstein monofilaments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A comprehensive clinical follow\u2010up was made 12\u2009months after AFT. Eighteen patients experienced a reduction of symptoms &gt;\u200950%. Ten of these were pain\u2010free. The pain level reduced from 8.7 to 3. A reduction of 85% of acute pain events per month was noted after surgery (from 23.6 to 4.6). Finally, a 74% reduction in medication intake was also seen. No complications were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AFT is a novel, regenerative approach for secondary occipital neuralgia. While more studies are needed to better understand the mechanisms of action, the results from this minimally invasive technique should be regarded as an important asset in regenerative medicine for treating post\u2010traumatic headaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70101","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T09:10:25Z","timestamp":1763025025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Minimally Invasive, Micro\u2010Autologous Fat Transfer for Secondary Occipital Neuralgia"],"prefix":"10.1111","volume":"26","author":[{"given":"Giorgio","family":"Pietramaggiori","sequence":"first","affiliation":[{"name":"Division of Aesthetic and Migraine Surgery Global Medical Institute  Lausanne Switzerland"},{"name":"Department of Neurosciences, Division of Plastic Surgery University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5122-0664","authenticated-orcid":false,"given":"Federico","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Division of Plastic Surgery University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bastin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Division of Plastic Surgery University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"L'Erario","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Division of Plastic Surgery University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Bassetto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Division of Plastic Surgery University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziv","family":"Peled","sequence":"additional","affiliation":[{"name":"Peled Plastic Surgery  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saja","family":"Scherer","sequence":"additional","affiliation":[{"name":"Division of Aesthetic and Migraine Surgery Global Medical Institute  Lausanne Switzerland"},{"name":"Department of Neurosciences, Division of Plastic Surgery University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"International Association for the Study of Pain \u201cIASP Taxonomy. Pain Terms. Neuropathic Pain\u201d https:\/\/www.iasp\u2010pain.org\/resources\/terminology\/#Neuropathicpain."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70143-5"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000282763.29778.59"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13276"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/204946370900300102"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2023.12.017"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005353"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02267.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-237"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477393"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30122"},{"key":"e_1_2_13_14_1","article-title":"Stromal Vascular Fraction\u2010Enriched Fat Grafting for the Treatment of Symptomatic End\u2010Neuromata","volume":"129","author":"Zimmermann S.","year":"2017","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2018.00010"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-50188-4"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181ef8beb"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182879f4a"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009777"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1717100"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.70101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.70101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:28:40Z","timestamp":1768382920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/papr.70101"],"URL":"https:\/\/doi.org\/10.1111\/papr.70101","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"2025-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70101"}}