{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:09:47Z","timestamp":1782439787144,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sacroiliitis is a debilitating condition causing significant lower back pain. Current treatment options, including medication, physical therapy, and invasive procedures, have limitations. High\u2010intensity focused ultrasound (HIFU) offers a noninvasive, image\u2010guided approach to treat chronic pain. In this study, we aimed to evaluate the safety and efficacy of HIFU for the treatment of sacroiliitis in patients with sacroiliac joint (SIJ) pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010arm, open\u2010label, pilot study was conducted on eight patients with SIJ pain. HIFU treatments were performed using a fluoroscopy\u2010guided system. Primary outcomes included pain intensity, functional disability, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HIFU procedure was well\u2010tolerated, with no significant adverse events reported. Patients demonstrated a statistically significant reduction in pain intensity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005) along with a nonsignificant improvement in functional disability and quality of life over the 6\u2010month follow\u2010up period. Additionally, MRI imaging confirmed precise ablation of the targeted tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIFU shows potential as a noninvasive treatment option for sacroiliitis. However, additional larger\u2010scale studies are needed to further explore these findings and refine treatment parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70134","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:41:05Z","timestamp":1773290465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Treatment of a Sacroiliitis Patient Using Fluoroscopy Guided High Intensity Focused Ultrasound for Sacroiliitis"],"prefix":"10.1111","volume":"26","author":[{"given":"Ruth","family":"Gur","sequence":"first","affiliation":[{"name":"Pain Center, Sheba Medical Center, Tel Hashomer  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Harel","sequence":"additional","affiliation":[{"name":"Pain Center, Sheba Medical Center, Tel Hashomer  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2637-8517","authenticated-orcid":false,"given":"Paz","family":"Kelmer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sheba Medical Center  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roee","family":"Sheinfeld","sequence":"additional","affiliation":[{"name":"Pain Center, Sheba Medical Center, Tel Hashomer  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oded","family":"Jacobi","sequence":"additional","affiliation":[{"name":"Pain Center, Sheba Medical Center, Tel Hashomer  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Goor\u2010Aryeh","sequence":"additional","affiliation":[{"name":"Pain Center, Sheba Medical Center, Tel Hashomer  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Ungar","sequence":"additional","affiliation":[{"name":"Pain Center, Sheba Medical Center, Tel Hashomer  Israel"},{"name":"Department of Neurosurgery Sheba Medical Center  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"228","article-title":"Bilateral Sacroiliitis Confirmed With Magnetic Resonance Imaging During Isotretinoin Treatment: Assessment of 11 Patients and a Review of the Literature","volume":"25","author":"Kocak O.","year":"2017","journal-title":"Acta Dermatovenerologica Croatica"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-219904"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2015\/18\/E713"},{"key":"e_1_2_14_5_1","first-page":"E305","article-title":"A Systematic Evaluation of Prevalence and Diagnostic Accuracy of Sacroiliac Joint Interventions","volume":"15","author":"Simopoulos T. 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