{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T02:30:21Z","timestamp":1783823421838,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010discharge opioid use patterns in opioid\u2010na\u00efve patients following cancer surgery remain poorly characterized, particularly during the early transition period after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the prevalence of continued opioid use 7\u2009days after discharge and to identify predictors and cessation trajectories over 30\u2009days post\u2010discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective single\u2010center cohort study enrolled opioid\u2010na\u00efve patients undergoing curative\u2010intent elective cancer surgery across three surgical specialties (breast, gynecological oncology, and head and neck) between June 2021 and January 2023. The primary outcome was patient\u2010reported opioid use at Day 7 post\u2010discharge. Multivariable logistic regression identified independent predictors; Kaplan\u2013Meier analysis estimated time\u2010to\u2010cessation by pre\u2010discharge opioid exposure group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 107 opioid\u2010na\u00efve patients, 42% continued opioid use beyond 7\u2009days. Patients who continued opioids had higher pain interference, more opioid\u2010related adverse events, and higher opioid consumption during 24 h prior to discharge (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.05). In multivariable analysis, having opioids in 24 h prior to discharge (adjusted odds ratio [aOR] 4.46; 95% CI 1.56\u201312.7), first\u2010time cancer surgery (aOR 6.06; 95% CI 1.45\u201325.6), and higher stage of cancer (aOR 1.50; 95% CI 1.00\u20132.23) were independently associated with continued opioid use. Kaplan\u2013Meier graph analysis demonstrated significantly different cessation trajectories between pre\u2010discharge opioid exposure groups (log rank\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continued opioid use in the first week following cancer surgery is common. Pre\u2010discharge opioid exposure and disease burden independently predict delayed cessation. Opioid use in the final 24 h before discharge represents a practical, clinically accessible signal for risk stratification and individualized opioid stewardship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70162","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:10:14Z","timestamp":1778242214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Patterns and Trajectory of Continued Opioid Use in Opioid\u2010Na\u00efve Patients After Curative\u2010Intent Elective Cancer Surgery\u2014A Prospective Cohort Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-4823","authenticated-orcid":false,"given":"Kenny Kwon Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy Chris O'Brien Lifehouse Hospital  Camperdown New South Wales Australia"},{"name":"Faculty of Medicine and Health, School of Pharmacy The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-6087","authenticated-orcid":false,"given":"Chin Hang","family":"Yiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Pharmacy The University of Sydney  Camperdown New South Wales Australia"},{"name":"Kolling Institute of Medical Research The Northern Sydney Local Health District  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Penm","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Pharmacy The University of Sydney  Camperdown New South Wales Australia"},{"name":"Department of Pharmacy Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Johns","sequence":"additional","affiliation":[{"name":"Department of Acute Pain Service Chris O'Brien Lifehouse Hospital  Camperdown New South Wales 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