{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:14:22Z","timestamp":1783426462745,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Persistent spinal pain syndrome (PSPS) with predominant low\u2010back pain (LBP) is difficult to manage when conservative and surgical treatments fail. Dorsal root ganglion stimulation (DRG\u2010S) offers segmental, focal neuromodulation that may be particularly suited for managing axial LBP, yet long\u2010term evidence from real\u2010world practice remains limited. This study evaluated the effectiveness, safety, and impact on medication use of bilateral T12 DRG\u2010S in patients with intractable LBP, using prospectively collected registry data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of 33 consecutive patients with chronic LBP assessed for DRG\u2010S, 20 underwent trial stimulation after multidisciplinary evaluation. Eighteen (90%) proceeded to permanent implantation following \u2265\u200950% pain reduction during trial. Patients were followed via a digital platform at 3, 6, 12, and 24\u2009months. Outcomes included pain intensity (NRS), quality of life (PROMIS\u201029), pain catastrophizing (PCS), satisfaction, medication use, and adverse events. Statistical comparisons were made between baseline and follow\u2010up time points using paired tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pain intensity decreased substantially and significantly across all follow\u2010up assessments: mean NRS declined from 8.0\u2009\u00b1\u20091.8 at baseline to 3.6\u2009\u00b1\u20091.6 at 3\u2009months, 3.2\u2009\u00b1\u20091.8 at 6\u2009months, 3.6\u2009\u00b1\u20091.7 at 12\u2009months, and 2.9\u2009\u00b1\u20091.6 at 24\u2009months (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 24\u2009months, 100% of patients achieved \u2265\u200930% pain reduction and 70% achieved \u2265\u200950% reduction. Patient\u2010reported outcomes demonstrated broad improvements. PROMIS\u201029 domains showed significant gains in physical function, pain interference, fatigue, and sleep disturbance, with consistent improvements also observed in anxiety and depression. Pain catastrophizing (PCS) scores decreased markedly, with total scores reduced by 47%\u201362% across follow\u2010ups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), reflecting improvements across helplessness, magnification, and rumination subdomains. Medication use declined over time. Mean opioid dose fell from 27\u2009mg\/day at baseline to 11.25\u2009mg\/day at 1\u2009year and 4.44\u2009mg\/day at 2\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019 and 0.011, respectively). Paracetamol use also decreased significantly, whereas gabapentinoid use remained variable. Seven hardware\u2010related complications were recorded (lead migration\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093, lead fracture\/damage\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), all successfully managed with revision surgery. Kaplan\u2013Meier analysis estimated mean time to complication at 1080\u2009days. Two patients discontinued therapy (EOT), both for reasons unrelated to device failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this prospective registry, bilateral T12 DRG\u2010S provided durable reduction in pain intensity, improved physical, psychosocial, and cognitive outcomes, and facilitated meaningful opioid\u2010sparing effects over 2\u2009years. Complications were limited to correctable hardware issues, and therapy discontinuation was rare. Although larger multicentre studies are warranted, these findings add important real\u2010world evidence supporting DRG\u2010S as a valuable therapeutic option for refractory axial LBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70183","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:33:49Z","timestamp":1782927229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Effectiveness and Safety of Dorsal Root Ganglion Stimulation for Persistent Spinal Pain Syndrome: Results From an Expanded Prospective Registry"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-7059","authenticated-orcid":false,"given":"Pedram","family":"Tabatabaei","sequence":"first","affiliation":[{"name":"Department of Clinical Science Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"V\u00e4nman","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Intervention Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","first-page":"e347","article-title":"Global Low Back Pain Prevalence and Years Lived With Disability From 1990 to 2020 With Projections to 2050: Findings From the Global Burden of Disease Study 2021","volume":"5","author":"Wu A.","year":"2023","journal-title":"Lancet Rheumatology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001390"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab015"},{"key":"e_1_2_12_5_1","volume-title":"Low Back Pain and Sciatica in Over 16s: Assessment and Management","author":"National Guideline Centre (UK)","year":"2020"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110033251405"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.23970\/AHRQEPCCER229"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2017.7415"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7918"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.07.028"},{"issue":"3","key":"e_1_2_12_11_1","article-title":"Spinal Cord Stimulation for Low Back Pain","volume":"3","author":"Traeger A. 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