{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:12:59Z","timestamp":1788876779925,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients. The aim of this study was to evaluate the efficacy on pain relief of ketamine and lidocaine mixtures versus lidocaine alone administered by mesotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This three\u2010arm, randomized, double\u2010blind trial compared mesotherapy with lidocaine 20\u2009mg alone or mixed with ketamine at a dose of 20\u2009mg or 40\u2009mg, in addition to standard treatment. The primary outcome was the difference in pain between inclusion and D56 after four mesotherapy sessions, assessed by a visual analog scale (VAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010one patients were randomized to receive lidocaine 20\u2009mg (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), lidocaine 20\u2009mg\u2009+\u2009ketamine 20\u2009mg (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911), or lidocaine 20\u2009mg\u2009+\u2009ketamine 40\u2009mg (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910). The mean difference in VAS score between inclusion and D56 was \u221225.60 (95% CI: \u221242.81, \u22128.39) in the lidocaine 20\u2009mg group, \u221210.13 (95% CI: \u221226.24, 5.99) in the lidocaine 20\u2009mg\u2009+\u2009ketamine 20\u2009mg group, and \u221219.06 (95% CI: \u221236.11, \u22122.02) in the lidocaine 20\u2009mg\u2009+\u2009ketamine 40\u2009mg group. There was no statistically significant\u00a0difference in change of VAS score between the 3 groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.36). No infectious or severe adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study did not demonstrate the superiority of mesotherapy with ketamine and lidocaine mixtures compared to lidocaine alone in relieving pain for CRPS1 patients. Lidocaine alone or mixed with ketamine can be administered safely with a rigorous mesotherapy procedure.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      The study was registered with\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , number NCT04650074, and EudraCT, number 2020\u2010005557\u201024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.70187","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:12:11Z","timestamp":1783570331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double\u2010Blind Trial"],"prefix":"10.1111","volume":"26","author":[{"given":"Philippe","family":"Lafuma","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon Groupement Hospitalier Centre Edouard Herriot, Service de Chirurgie Orthop\u00e9dique et Urgences Traumatologiques du Membre Inf\u00e9rieur  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Magaud","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon P\u00f4le de Sant\u00e9 Publique, Service Recherche et Epid\u00e9miologie Cliniques  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3052-7335","authenticated-orcid":false,"given":"Amna","family":"Abichou\u2010Klich","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon Service de Biostatistique\u2010Bioinformatique  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, UMR 5558, CNRS  Villeurbanne 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