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However, protection of cattle against viral infections is still a major concern in veterinary science. During the last two decades, the development of efficient plant\u2010based expression strategies for recombinant proteins prompted the application of this methodology for veterinary vaccine purposes. The main goals of viral bovine vaccines are to improve the health and welfare of cattle and increase the production of livestock, in a cost\u2010effective manner. This review explores some of the more prominent recent advances in plant\u2010made viral bovine vaccines against foot\u2010and\u2010mouth disease virus (<jats:styled-content style=\"fixed-case\">FMDV<\/jats:styled-content>), bovine rotavirus (<jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content>), bovine viral diarrhoea virus (<jats:styled-content style=\"fixed-case\">BVDV<\/jats:styled-content>), bluetongue virus (<jats:styled-content style=\"fixed-case\">BTV<\/jats:styled-content>) and bovine papillomavirus (<jats:styled-content style=\"fixed-case\">BPV<\/jats:styled-content>), some of which are considered to be the most important viral causative agents of economic loss in cattle production.<\/jats:p>","DOI":"10.1111\/pbi.12440","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T14:18:59Z","timestamp":1438870739000},"page":"1071-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Plant\u2010produced viral bovine vaccines: what happened during the last 10\u00a0years?"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-2819","authenticated-orcid":false,"given":"Vanesa","family":"Ruiz","sequence":"first","affiliation":[{"name":"Instituto de Virolog\u00eda CICVyA INTA Hurlingham Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina V.","family":"Mozgovoj","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda CICVyA INTA Hurlingham Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Dus Santos","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda CICVyA INTA Hurlingham Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Wigdorovitz","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda CICVyA INTA Hurlingham Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.12.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297911030072"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30460-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.10.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(93)90016-D"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30470-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2008022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.02.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.11.013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.13031\/2013.26854"},{"key":"e_1_2_8_13_1","first-page":"10","article-title":"Plant\u2010made biologics","volume":"2014","author":"Chen Q.","year":"2014","journal-title":"Biomed Res. 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