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All\n                    <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\n                    \u2010approved immunoadhesins are designed to modulate the interaction of a human receptor with its normal ligand, such as Etanercept (Enbrel\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ), which interferes with the binding of tumour necrosis factor (\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    ) to the\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010alpha receptor and is used to treat inflammatory diseases such as rheumatoid arthritis. Like antibodies, immunoadhesins have long circulating half\u2010lives, are readily purified by affinity\u2010based methods and have the avidity advantages conferred by bivalency. Immunoadhesins that incorporate normal cellular receptors for viruses or bacterial toxins hold great, but as yet unrealized, potential for treating infectious disease. As decoy receptors, immunoadhesins have potential advantages over pathogen\u2010targeted monoclonal antibodies. Planet Biotechnology has specialized in developing anti\u2010infective immunoadhesins using plant expression systems. An immunoadhesin incorporating the cellular receptor for anthrax toxin,\n                    <jats:styled-content style=\"fixed-case\">CMG<\/jats:styled-content>\n                    2, potently blocks toxin activity\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    and protects animals against inhalational anthrax. An immunoadhesin based on the receptor for human rhinovirus,\n                    <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\n                    \u20101, potently blocks infection of human cells by one of the major causes of the common cold. An immunoadhesin targeting the\n                    <jats:styled-content style=\"fixed-case\">MERS<\/jats:styled-content>\n                    coronavirus is in an early stage of development. We describe here the unique challenges involved in designing and developing immunoadhesins targeting infectious diseases in the hope of inspiring further research into this promising class of drugs.\n                  <\/jats:p>","DOI":"10.1111\/pbi.12441","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T23:39:25Z","timestamp":1438731565000},"page":"1078-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Anti\u2010infective immunoadhesins from plants"],"prefix":"10.1111","volume":"13","author":[{"given":"Keith","family":"Wycoff","sequence":"first","affiliation":[{"name":"Planet Biotechnology Inc. Hayward CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Maclean","sequence":"additional","affiliation":[{"name":"Planet Biotechnology Inc. 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