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Grain aphid\n                    <jats:italic>Sitobion miscanthi<\/jats:italic>\n                    is an important wheat pest worldwide. However, the molecular basis for the regulation of the plant resistance to cereal aphids remains largely unknown. Here, we show that SmCSP4, a chemosensory protein from\n                    <jats:italic>S. miscanthi<\/jats:italic>\n                    saliva, is secreted into wheat plants during aphid feeding. Delivery of SmCSP4 into wheat leaves activates salicylic acid (SA)\u2010mediated plant defence responses and subsequently reduces aphid performance by deterring aphid feeding behaviour. In contrast, silencing\n                    <jats:italic>SmCSP4<\/jats:italic>\n                    gene via nanocarrier\u2010mediated RNAi significantly decreases the ability of aphids to activate SA defence pathway. Protein\u2013protein interaction assays showed that SmCSP4 directly interacts with wheat transcriptional factor TaWRKY76 in plant nucleus. Furthermore, TaWRKY76 directly binds to the promoter of SA degradation gene\n                    <jats:italic>Downy Mildew Resistant 6<\/jats:italic>\n                    (\n                    <jats:italic>DMR6<\/jats:italic>\n                    ) and regulates its gene expression as transcriptional activator. SmCSP4 secreted by aphids reduces the transcriptional activation activity of TaWRKY76 on\n                    <jats:italic>DMR6<\/jats:italic>\n                    gene expression, which is proposed to result in increases of SA accumulation and enhanced plant immunity. This study demonstrated that SmCSP4 acts as salivary elicitor that is involved in activating SA signalling defence pathway of wheat by interacting with TaWRKY76, which provide novel insights into aphid\u2010cereal crops interactions and the molecular mechanism on induced plant immunity.\n                  <\/jats:p>","DOI":"10.1111\/pbi.14139","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T11:30:29Z","timestamp":1691148629000},"page":"2389-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["SmCSP4 from aphid saliva stimulates salicylic acid\u2010mediated defence responses in wheat by interacting with transcription factor TaWKRY76"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-2405","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[{"name":"PHIM Plant Health Institute Univ Montpellier, INRAE, CIRAD, Institut Agro, IRD  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Francis","sequence":"additional","affiliation":[{"name":"Functional and Evolutionary Entomology, Gembloux Agro\u2010Bio Tech University of Li\u00e8ge  Gembloux Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences  Beijing China"},{"name":"Department of Entomology, College of Plant Protection China Agricultural University  Beijing 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