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The growing challenge of pest resistance, coupled with the relatively low success rates of pesticides, has prompted researchers to shift their attention towards the accurate evaluation\u00a0of insecticide lead. In contrast to in\u00a0vitro methods of structural similarity or target affinity, the \u2018insecticide\u2010likeness\u2019 approach emphasises the in\u00a0vivo biological effects of compounds, thereby constructing precise and comprehensive evaluation rules. In the present study, a multi\u2010scale qualitative\u2010quantitative insecticide\u2010likeness evaluation platform, Agrochem Predictive Platform for Insecticide\u2010likeness (APPi), was developed. An APPi rule was proposed for qualitative evaluation (ClogP \u2264\u20097, ARB \u2264\u200918, HBA \u2264\u20097, HBD \u2264\u20092, PFI \u2264\u20098 and ROB \u2264\u200910). A quantitative insecticide\u2010likeness evaluation model, the APPi model, was developed based on a multi\u2010classifier integrated machine learning framework (PUMV). The APPi model demonstrated excellent performance on the train and external test sets. Crucially, on the independent external test set, it achieved an accuracy of 85%, which represents a significant improvement over existing models. Furthermore, we developed the FragScore Visualiser tool to identify critical insecticidal fragments of compounds. The APPi platform provides precise guidance for virtual screening and structure optimisation of lead compounds in the early stage of insecticides discovery. The platform is available free of charge at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/pesticides.cau.edu.cn\/APPi\">http:\/\/pesticides.cau.edu.cn\/APPi<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/pbi.70271","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T09:30:48Z","timestamp":1753176648000},"page":"4844-4856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["APPi: A Multiscale Qualitative\u2013Quantitative Insecticide\u2010Likeness Evaluation Platform and Application"],"prefix":"10.1111","volume":"23","author":[{"given":"Jia\u2010lin","family":"Cui","sequence":"first","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin\u2010yan","family":"Jin","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Eco\u2010Environmental Sciences Chinese Academy of Science  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Center for Eco\u2010Environmental Sciences Chinese Academy of Science  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-1092","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103366"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-020-0209-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoinf.2020.101137"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1243"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555219859845"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1145\/2939672.2939785"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03821"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2024.108113"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ac2206"},{"key":"e_1_2_8_13_1","unstructured":"FAO.2023. \u201cThe Impact of Disasters on Agriculture and Food Security: Avoiding and Reducing Losses Through Investment in Resilience.\u201d"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013203451"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipm.2014.11.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10994-006-6226-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c08587"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201100020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00843"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c00522"},{"key":"e_1_2_8_21_1","volume-title":"Advances in Neural Information Processing Systems","author":"Ke G. 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