{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:41:21Z","timestamp":1788583281530,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801699"],"award-info":[{"award-number":["31801699"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372486"],"award-info":[{"award-number":["32372486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010890","name":"Chinese Government Scholarship","doi-asserted-by":"publisher","award":["FileNo.202108320223"],"award-info":[{"award-number":["FileNo.202108320223"]}],"id":[{"id":"10.13039\/501100010890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biotechnology Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood. Fibrillin (FBN) proteins are primarily localised to chloroplasts and are intimately linked with lipid metabolism and stress responses in chloroplasts. Here, we report that NbLIP1, a light\u2010induced FBN1 family protein in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    , directly interacts with the coat protein (CP) of rehmannia mosaic virus (ReMV) and other related tobamoviruses (TMV, YoMV). Upon viral infection, this interaction leads to the relocalisation of NbLIP1 from chloroplasts to ER\u2010proximal viral replication sites. Functional assays demonstrated that overexpression of NbLIP1 significantly enhanced viral replication, viral protein accumulation, and VRO formation, while silencing NbLIP1 had the opposite effects. These findings unveil a novel viral infection mechanism whereby the viral CP hijacks the host lipid transfer protein NbLIP1 and recruits it to viral replication factories to promote viral replication, potentially by modulating lipid supply or the microenvironment remodelling at the replication sites. This study not only elucidates the role of NbLIP1 as a novel pro\u2010viral host factor but also provides new insights into how viruses exploit host resources across cellular compartments, suggesting NbLIP1 as a potential antiviral target.\n                  <\/jats:p>","DOI":"10.1111\/pbi.70497","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:43:06Z","timestamp":1765888986000},"page":"2419-2438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tobamoviruses\n                    <scp>CP<\/scp>\n                    Proteins Hijack Light\u2010Induced Protein (\n                    <scp>NbLIP1<\/scp>\n                    ) to Promote Viral Replication by Facilitating\n                    <scp>VRO<\/scp>\n                    Formation"],"prefix":"10.1111","volume":"24","author":[{"given":"Haoyu","family":"Chen","sequence":"first","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hua","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Hua","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"He","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Moffett","sequence":"additional","affiliation":[{"name":"Centre S\u00c8VE, D\u00e9partement de Biologie Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-3465","authenticated-orcid":false,"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Plant Protection Yangzhou University  Yangzhou Jiangsu P. R. China"},{"name":"Joint International Research Laboratory of Agriculture and Agri\u2010Product Safety of Ministry of Education of China Yangzhou University  Yangzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307778101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000705"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004087"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.00804"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.08.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818654-1.00014-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-052521-115736"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.6.1.119"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004742"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2024.1453974"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065477"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.06.024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.20.00369"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031620"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04728-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.10.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/342837a0"},{"key":"e_1_2_9_19_1","first-page":"2956","article-title":"Fibrillin 5 Is Essential for Plastoquinone\u20109 Biosynthesis by Binding to Solanesyl Diphosphate Synthases in Arabidopsis","volume":"27","author":"Kim E. 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