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Here, we profiled H3K27me3 dynamics in\n                    <jats:italic>Fusarium graminearum<\/jats:italic>\n                    during infection and identified 132 H3K27me3\u2010marked genes (\n                    <jats:italic>FgHMGs<\/jats:italic>\n                    ). Among these,\n                    <jats:italic>FgHMG1<\/jats:italic>\n                    encodes a secreted glycoside hydrolase family 11 (GH11) protein that functions as a pathogen\u2010associated molecular pattern (PAMP), triggering PAMP\u2010triggered immunity (PTI) in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    through the receptor kinases BAK1 and SOBIR1, independently of its enzymatic activity. FgHMG1 also induces reactive oxygen species (ROS) accumulation and upregulation of defence\u2010related genes in wheat plants. Remarkably, FgHMG1 expression is repressed during host invasion by the histone methyltransferase FgKMT6, a homologue of Enhancer of zeste (E(z)) from Drosophila, via H3K27me3 deposition, enabling immune evasion. Loss of FgKMT6 abolishes H3K27me3 enrichment, derepresses FgHMG1, and enhances host immunity, effects largely rescued in\n                    <jats:italic>\u0394FgKMT6\u2013FgHMG1<\/jats:italic>\n                    double mutants. Notably, foliar application of recombinant FgHMG1 protein reduced Fusarium head blight severity in wheat by 35%\u201350% in 2\u2010year field trials. These findings reveal that fungal pathogens exploit H3K27me3\u2010mediated silencing of immunogenic PAMP genes to evade host recognition and highlight FgHMG1 as a promising candidate for crop protection.\n                  <\/jats:p>","DOI":"10.1111\/pbi.70530","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:36:22Z","timestamp":1767710182000},"page":"2843-2857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>H3K27me3<\/scp>\n                    \u2010Mediated Epigenetic Silencing of\n                    <scp>\n                      <i>FgHMG1<\/i>\n                    <\/scp>\n                    Enables Fungal Host Immune Evasion"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaozhen","family":"Zhao","sequence":"first","affiliation":[{"name":"Anhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection Anhui Agricultural 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