{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:26:43Z","timestamp":1786706803363,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biotechnology Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rice fragrance is a key determinant of grain quality, yet the aroma profile of cultivated rice is highly uniform and largely dominated by the popcorn\u2010like compound 2\u2010acetyl\u20101\u2010pyrroline. Here we expanded the aromatic repertoire of rice by engineering a rose\u2010like fragrance through reconstruction of the phenylalanine\u2010derived 2\u2010phenylethanol (2\u2010PE) pathway in the endosperm. To increase phenylalanine precursor supply, we co\u2010expressed an engineered G211R\/G212S variant of the rice 3\u2010deoxy\u2010D\u2010arabino\u2010heptulosonate 7\u2010phosphate synthase isoform OsDHS2 (\n                    <jats:italic>LOC_Os08g37790<\/jats:italic>\n                    ; mOsDHS2) with heterologous phenylacetaldehyde synthase (PAAS) and phenylacetaldehyde reductase (PAR) in the endosperm. As a result, the engineered grains accumulated up to 2014\u2009\u03bcg\/kg 2\u2010PE, conferring a distinct rose\u2010like aroma. Unexpectedly, metabolic rewiring also reshaped grain composition, resulting in nearly doubled soluble protein content and increased levels of several vitamin B6\u2010related metabolites, including the active coenzyme forms pyridoxal 5\u2032\u2010phosphate and pyridoxamine 5\u2032\u2010phosphate. These findings reveal extensive associated metabolic coordination between aromatic amino acid pathways and central seed metabolism. Our work establishes a strategy for creating designer fragrances in staple crops while simultaneously improving nutritional traits, providing a versatile platform for producing high\u2010value metabolites in cereal grains.\n                  <\/jats:p>","DOI":"10.1111\/pbi.70743","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:26:51Z","timestamp":1786703211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Rewiring of the Shikimate Pathway Enables Rose\u2010Scented Rice"],"prefix":"10.1111","author":[{"given":"Xiaoqing","family":"Cui","sequence":"first","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"},{"name":"Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs South China Agricultural University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"},{"name":"Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs South China Agricultural University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"},{"name":"Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs South China Agricultural University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangning","family":"Ou","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-6266","authenticated-orcid":false,"given":"Chengxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8141-7282","authenticated-orcid":false,"given":"Wenyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"},{"name":"Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs South China Agricultural University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-6574","authenticated-orcid":false,"given":"Jiayang","family":"Li","sequence":"additional","affiliation":[{"name":"Yazhouwan National Laboratory  Sanya China"},{"name":"Institute of Genetics and Developmental Biology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Eco\u2010Circular Agriculture, College of Natural Resources and Environment South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5276-8271","authenticated-orcid":false,"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Institute of Water\u2010Saving and Drought\u2010Resistance Rice Green Industry, College of Agriculture South China Agricultural University  Guangzhou China"},{"name":"Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs South China Agricultural University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/ncomms16018","article-title":"The Self\u2010Inhibitory Nature of Metabolic Networks and Its Alleviation Through Compartmentalization","volume":"8","author":"Alam M. 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G.","year":"1983","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41588-025-02429-2","article-title":"Natural Variation in OsTPS8 Confers Differential Regulation of Chalkiness and Seed Vigor in Indica and Japonica Rice","volume":"58","author":"Chen X.","year":"2026","journal-title":"Nature Genetics"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jplph.2010.06.011","article-title":"Functional Characterization of Rose Phenylacetaldehyde Reductase (PAR), an Enzyme Involved in the Biosynthesis of the Scent Compound 2\u2010Phenylethanol","volume":"168","author":"Chen X. M.","year":"2011","journal-title":"Journal of Plant Physiology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1038\/s41598-019-38837-8","article-title":"Nitrogen Availability Alters Flavonoid Accumulation in Cyclocarya paliurus via the Effects on the Internal Carbon\/Nitrogen Balance","volume":"9","author":"Deng B.","year":"2019","journal-title":"Scientific Reports"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.1093\/plphys\/kiaf366","article-title":"Re\u2010Tuning of Aromatic Amino Acid Biosynthesis Before and After the Evolution of Tyrosine\u2010Derived Grass Lignin","volume":"199","author":"El\u2010Azaz J.","year":"2025","journal-title":"Plant Physiology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42587-7","article-title":"Coordinated Regulation of the Entry and Exit Steps of Aromatic Amino Acid Biosynthesis Supports the Dual Lignin Pathway in Grasses","volume":"14","author":"El\u2010Azaz J.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/abbi.1993.1575","article-title":"Threonine Synthase of \n                     Escherichia coli\n                  : Inhibition by Classical and Slow\u2010Binding Analogues of Homoserine Phosphate","volume":"307","author":"Farrington G. K.","year":"1993","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/oxfordjournals.pcp.a076054","article-title":"3\u2010Deoxy\u2010D\u2010Arabino Heptulosonate 7\u2010Phosphate Synthase From \n                     Zea mays\n                  : General Properties and Regulation by Tryptophan","volume":"21","author":"Graziana A.","year":"1980","journal-title":"Plant and Cell Physiology"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12870-026-08192-8","article-title":"Foliar Application of Allantoin Reinforces Antioxidant Defense and Glyoxalase Systems to Confer Tolerance Against Arsenic Toxicity in Rice (\n                     Oryza sativa\n                   L.)","volume":"26","author":"Hasanuzzaman M.","year":"2026","journal-title":"BMC Plant Biology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1128\/AEM.02625-07","article-title":"The Ehrlich Pathway for Fusel Alcohol Production: A Century of Research on \n                     Saccharomyces cerevisiae\n                   Metabolism","volume":"74","author":"Hazelwood L. A.","year":"2008","journal-title":"Applied and Environmental Microbiology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/17429145.2018.1478007","article-title":"Resistance\u2010Related Physiological Response of Rice Leaves to the Compound Stress of Enhanced UV\u2010B Radiation and Magnaporthe oryzae","volume":"13","author":"He Y.","year":"2018","journal-title":"Journal of Plant Interactions"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/molecules15010442","article-title":"Vitamin B6: A Molecule for Human Health","volume":"15","author":"Hellmann H.","year":"2010","journal-title":"Molecules"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1016\/S0021-9258(19)42135-2","article-title":"Regulation of Aromatic Amino Acid Biosynthesis in Higher Plants. II. 3\u2010Deoxy\u2010Arabino\u2010Heptulosonic Acid 7\u2010Phosphate Synthetase From Cauliflower","volume":"249","author":"Huisman O. C.","year":"1974","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.sbi.2020.06.015","article-title":"Diverse Allosteric Componentry and Mechanisms Control Entry Into Aromatic Metabolite Biosynthesis","volume":"65","author":"Jiao W.","year":"2020","journal-title":"Current Opinion in Structural Biology"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"23357","DOI":"10.1074\/jbc.M602708200","article-title":"Plant Phenylacetaldehyde Synthase Is a Bifunctional Homotetrameric Enzyme That Catalyzes Phenylalanine Decarboxylation and Oxidation","volume":"281","author":"Kaminaga Y.","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12284-016-0100-y","article-title":"Proteomic and Glycomic Characterization of Rice Chalky Grains Produced Under Moderate and High\u2010Temperature Conditions in Field System","volume":"9","author":"Kaneko K.","year":"2016","journal-title":"Rice"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1663\/0006-8101(2006)72[1:DADOFS]2.0.CO;2","article-title":"Diversity and Distribution of Floral Scent","volume":"72","author":"Knudsen J. T.","year":"2006","journal-title":"Botanical Review"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/tpj.16310","article-title":"Natural Variations in the Sl\u2010AKR9 Aldo\/Keto Reductase Gene Impact Fruit Flavor Volatile and Sugar Contents","volume":"115","author":"Li X.","year":"2023","journal-title":"Plant Journal"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/plants14020244","article-title":"Molecular Mechanisms of Grain Chalkiness Variation in Rice Panicles","volume":"14","author":"Li Z.","year":"2025","journal-title":"Plants"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1094\/CCHEM-10-13-0218-R","article-title":"Suitability of Ontario\u2010Grown Hard and Soft Wheat Flour Blends for Noodle Making","volume":"91","author":"Lu Z.","year":"2014","journal-title":"Cereal Chemistry"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.tplants.2020.02.005","article-title":"Aromatic Amino Acids: A Complex Network Ripe for Future Exploration","volume":"25","author":"Lynch J. H.","year":"2020","journal-title":"Trends in Plant Science"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-arplant-042811-105439","article-title":"The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants","volume":"63","author":"Maeda H.","year":"2012","journal-title":"Annual Review of Plant Biology"},{"key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/molecules14010329","article-title":"Vitamin B6: A Long Known Compound of Surprising Complexity","volume":"14","author":"Mooney S.","year":"2009","journal-title":"Molecules"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1136\/gutjnl-2025-335577","article-title":"Rice\u2010Derived Recombinant Human Serum Albumin as an Alternative to Human Plasma for Patients With Decompensated Liver Cirrhosis: A Randomised, Double\u2010Blind, Positive\u2010Controlled and Non\u2010Inferiority Trial","volume":"74","author":"Niu J.","year":"2025","journal-title":"Gut"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2024.1470316","article-title":"The OsGAPC3 Mutation Significantly Affects Grain Quality Traits and Improves the Nutritional Quality of Rice","volume":"15","author":"Peng B.","year":"2024","journal-title":"Frontiers in Plant Science"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/sj.embor.embor914","article-title":"A Genomic Overview of Pyridoxal Phosphate\u2010Dependent Enzymes","volume":"4","author":"Percudani R.","year":"2003","journal-title":"EMBO Reports"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1118510","article-title":"Biosynthesis of Plant Volatiles: Nature's Diversity and Ingenuity","volume":"311","author":"Pichersky E.","year":"2006","journal-title":"Science"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00299-015-1790-0","article-title":"Metabolic Engineering of 2\u2010Phenylethanol Pathway Producing Fragrance Chemical and Reducing Lignin in Arabidopsis","volume":"34","author":"Qi G.","year":"2015","journal-title":"Plant Cell Reports"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0304-4211(82)90088-8","article-title":"3\u2010Deoxy\u2010d\u2010Arabino\u2010Heptulosonate 7\u2010Phosphate Synthase From Pea Leaves: Inhibition by L\u2010Tyrosine","volume":"26","author":"Reinink M.","year":"1982","journal-title":"Plant Science Letters"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/cne.23802","article-title":"Role of Ortho\u2010Retronasal Olfaction in Mammalian Cortical Evolution","volume":"524","author":"Rowe T. B.","year":"2016","journal-title":"Journal of Comparative Neurology"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1271\/bbb.70090","article-title":"Production of 2\u2010Phenylethanol in Roses as the Dominant Floral Scent Compound From L\u2010Phenylalanine by Two Key Enzymes, a PLP\u2010Dependent Decarboxylase and a Phenylacetaldehyde Reductase","volume":"71","author":"Sakai M.","year":"2007","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1365-313X.2008.03446.x","article-title":"Biosynthesis of Plant\u2010Derived Flavor Compounds","volume":"54","author":"Schwab W.","year":"2008","journal-title":"Plant Journal"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1111\/pbi.14420","article-title":"Natural Variation of WBR7 Confers Rice High Yield and Quality by Modulating Sucrose Supply in Sink Organs","volume":"22","author":"Shi H.","year":"2024","journal-title":"Plant Biotechnology Journal"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0022-2836(02)00545-4","article-title":"Allosteric Inhibition of 3\u2010Deoxy\u2010D\u2010Arabino\u2010Heptulosonate\u20107\u2010Phosphate Synthase Alters the Coordination of Both Substrates","volume":"320","author":"Shumilin I. A.","year":"2002","journal-title":"Journal of Molecular Biology"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/pbi.13863","article-title":"A Whiff of the Future: Functions of Phenylalanine\u2010Derived Aroma Compounds and Advances in Their Industrial Production","volume":"20","author":"Skaliter O.","year":"2022","journal-title":"Plant Biotechnology Journal"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1104\/pp.79.3.765","article-title":"3\u2010Deoxy\u2010d\u2010Arabino\u2010Heptulosonate 7\u2010Phosphate Synthase From Carrot Root (\n                     Daucus carota\n                  ) is a Hysteretic Enzyme","volume":"79","author":"Suzich J. A.","year":"1985","journal-title":"Plant Physiology"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"kiaf416","DOI":"10.1093\/plphys\/kiaf416","article-title":"eRUBY Rice: Co\u2010Expression of a Feedback\u2010Insensitive TyrA Arogenate Dehydrogenase With RUBY Enhances Endosperm Betalain Levels","volume":"199","author":"Tan J.","year":"2025","journal-title":"Plant Physiology"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/pbi.13059","article-title":"Enhancing Carotenoid Biosynthesis in Rice Endosperm by Metabolic Engineering","volume":"17","author":"Tian Y. 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