{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:12:18Z","timestamp":1788783138880,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1200403"],"award-info":[{"award-number":["2023YFD1200403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biotechnology Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large\u2010scale metabolome analysis using liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) and 33 grain\u2010related traits in a diverse panel of natural accessions and a recombinant inbred line (RIL) population. We identified a new network of 2286 associations between 947 metabolites and 33 grain\u2010related traits. Systematic integration of metabolic genome\u2010wide association study (mGWAS) and metabolic quantitative trait locus (mQTL) analyses identified 33\u2009566 significant single\u2010nucleotide polymorphisms (SNPs) and 3128 mQTL. Thirteen annotated metabolites co\u2010localized within a physical interval on 7A. Integration of metabolite\u2010based and phenotype\u2010based GWAS and QTL revealed an overlapped region for gibberellin A4 (GA4) content and grain roundness on 4A. Phenotyping of an ethyl methanesulfonate (EMS)\u2010induced mutant confirmed the role of\n                    <jats:italic>TaSDR<\/jats:italic>\n                    in regulating GA4 content and grain morphology. These findings provide novel insights into the metabolic pathways influencing key grain\u2010related traits and advance our understanding of the complex molecular mechanisms regulating grain metabolites and phenotypes in wheat. The identified metabolic markers and candidate genes provide valuable targets for molecular breeding programs aimed at improving wheat yield and quality.\n                  <\/jats:p>","DOI":"10.1111\/pbi.70755","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:30:51Z","timestamp":1788780651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Genome\u2010Wide Association Studies of Metabolites and Grain\u2010Related Traits in Common Wheat"],"prefix":"10.1111","author":[{"given":"Guoguo","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, College of Agronomy Henan Agricultural University  Zhengzhou China"},{"name":"Henan Engineering Research Center of Crop Genome Editing, State Key Laboratory of High\u2010Efficiency Production of Wheat\u2010Maize Double Cropping, School 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