{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:53:08Z","timestamp":1791438788551,"version":"4.3.3"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272194"],"award-info":[{"award-number":["32272194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1200300"],"award-info":[{"award-number":["2022YFD1200300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS\u201015\u201005"],"award-info":[{"award-number":["CARS\u201015\u201005"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biotechnology Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fruit size is not only a crucial fitness trait in plant evolution but also an important agronomic target in crop domestication and improvement, yet its regulatory mechanisms remain poorly characterized. Here, we identified an F\u2010box E3 ubiquitin ligase gene,\n                    <jats:italic>GhEBS1<\/jats:italic>\n                    (\n                    <jats:italic>ENLARGED BOLL SIZE 1<\/jats:italic>\n                    ), as a positive regulator of cotton boll size via map\u2010based cloning. An 845\u2010bp structural variant in the promoter\u2010proximal intronic region of\n                    <jats:italic>GhEBS1<\/jats:italic>\n                    alters local chromatin accessibility and histone modifications, specifically H3K27 and H3K9 methylation levels and acetylation, thereby modulating\n                    <jats:italic>GhEBS1<\/jats:italic>\n                    expression and driving boll size divergence. Overexpression or heterologous expression of\n                    <jats:italic>GhEBS1<\/jats:italic>\n                    in cotton (capsule), tomato (berry) and\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    (silique) promoted fruit enlargement, indicating its functional conservation. Further analysis showed that GhEBS1 interacts with GhPPD1\/2 and GhKIX8\/9 to modulate downstream cell proliferation\u2010related genes to control cell number and boll size. Breeding evaluations confirm that the elite\n                    <jats:italic>GhEBS1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>L<\/jats:italic>\n                    <\/jats:sup>\n                    allele significantly increases boll size, seed size and boll weight. Haplotype analysis reveals that\n                    <jats:italic>GhEBS1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>L<\/jats:italic>\n                    <\/jats:sup>\n                    originated from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Gossypium hirsutum<\/jats:italic>\n                    <\/jats:styled-content>\n                    race\n                    <jats:italic>latifolium<\/jats:italic>\n                    and underwent artificial selection during cotton domestication. Our findings provide new insights into the regulation of plant fruit size and present a valuable genetic locus for crop yield improvement.\n                  <\/jats:p>","DOI":"10.1111\/pbi.70761","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:12:32Z","timestamp":1791436352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Intronic Structural Variant in\n                    <scp>\n                      <i>GhEBS1<\/i>\n                    <\/scp>\n                    Drives Cotton Fruit Size Divergence by Modulating Chromatin Accessibility and Gene Expression"],"prefix":"10.1111","author":[{"given":"Furong","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangqiang","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehan","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhecheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization, Institute of Cotton Research Chinese Academy of Agricultural Sciences  Anyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Lei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"},{"name":"College of Life Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"},{"name":"College of Life Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohai","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"},{"name":"College of Life Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"},{"name":"College of Life Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanban","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoupu","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cotton Bio\u2010Breeding and Integrated Utilization, Institute of Cotton Research Chinese Academy of Agricultural Sciences  Anyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-4547","authenticated-orcid":false,"given":"Tianzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-3686","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cotton Breeding and Cultivation in Huang\u2010Huai\u2010Hai Plain, Ministry of Agriculture and Rural Affairs, Institute of Industrial Crops Shandong Academy of Agricultural Sciences  Jinan China"},{"name":"College of Life Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1093\/plcell\/koab119","article-title":"Ectopic Expression of \n                     Triticum polonicum VRT\u2010A2 Underlies Elongated Glumes and Grains in Hexaploid Wheat in a Dosage\u2010Dependent Manner","volume":"33","author":"Adamski N. 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