{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:43:54Z","timestamp":1792053834022,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2023365"],"award-info":[{"award-number":["BE2023365"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS\u201028"],"award-info":[{"award-number":["CARS\u201028"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573001"],"award-info":[{"award-number":["32573001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biotechnology Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Stone cell lignification is a key determinant of pear fruit texture and commercial quality, and this process has been reported to be tightly coupled to cellular glucose availability. However, how glucose dose\u2010dependently targets transcription factor phosphorylation during lignin biosynthesis remains largely unknown. Using yeast two\u2010hybrid library screening and phosphorylation assays, we found that PbSnRK1, a glucose\u2010responsive kinase, interacts with and directly phosphorylates PbTCP13, thereby participating in the regulation of stone cell lignification. PbSnRK1 serves as an energy\u2010status sensor linking glucose signalling to biphasic regulation of lignin metabolism in pear. Under low\u2010glucose conditions, activated PbSnRK1 phosphorylates the transcription factor PbTCP13 at Ser265, targeting it for 26S proteasome\u2010mediated degradation and thereby derepressing PbMYB11\u2010\n                    <jats:italic>PbCCR1<\/jats:italic>\n                    cascade associated with lignin biosynthesis. Under high\u2010glucose conditions, suppressed PbSnRK1 kinase activity results in PbTCP13 protein accumulation, which restricts excessive lignification by both repressing\n                    <jats:italic>PbCCR1<\/jats:italic>\n                    transcription and physically interacting with PbMYB11 to inhibit its transactivation capacity. This PbSnRK1\u2010PbTCP13\u2010PbMYB11 cascade, balanced by glucose concentration, acts as a molecular switch that activates stone cell formation and lignification at low\u2010glucose levels during early fruit development, while restricting excessive lignification at high\u2010glucose levels during later stages, providing new mechanistic insights into energy\u2010coupled secondary wall metabolism in fleshy fruits.\n                  <\/jats:p>","DOI":"10.1111\/pbi.70770","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:44:03Z","timestamp":1792050243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>PbSnRK1<\/scp>\n                    \u2010Mediated Phosphorylation of\n                    <scp>PbTCP13<\/scp>\n                    Regulates Glucose\u2010Responsive Lignin Biosynthesis via\n                    <scp>PbMYB11<\/scp>\n                    During Pear Stone Cell Formation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7704-0521","authenticated-orcid":false,"given":"Jianan","family":"He","sequence":"first","affiliation":[{"name":"Sanya Institute, State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Sanya Institute, State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3422-581X","authenticated-orcid":false,"given":"Abdul","family":"Basit","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Sanya Institute, State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Chao","sequence":"additional","affiliation":[{"name":"Sanya Institute, State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sanya Institute, State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University  Nanjing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-7912","authenticated-orcid":false,"given":"Katsuhiro","family":"Shiratake","sequence":"additional","affiliation":[{"name":"Laboratory of Horticultural Science, Graduate School of Bioagricultural Sciences Nagoya University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-2252","authenticated-orcid":false,"given":"Khanizadeh","family":"Shahrokh","sequence":"additional","affiliation":[{"name":"Elm Consulting Genetic Research  St\u2010Lazare Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-8865","authenticated-orcid":false,"given":"Shutian","family":"Tao","sequence":"additional","affiliation":[{"name":"Sanya Institute, State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University  Nanjing 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