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UGT73B3<\/jats:italic><\/jats:styled-content> and UGT73B5<\/jats:italic><\/jats:styled-content>, two UGTs<\/jats:styled-content><\/jats:italic> of A<\/jats:styled-content>rabidopsis thaliana<\/jats:italic> (A<\/jats:styled-content>rabidopsis), are involved in the hypersensitive response (HR<\/jats:styled-content>) to the avirulent bacteria P<\/jats:styled-content>seudomonas syringae<\/jats:italic> pv. tomato<\/jats:italic> (Pst\u2010AvrRpm1<\/jats:italic><\/jats:styled-content>), but their function in planta<\/jats:italic> is unknown. Here, we report that ugt73b3<\/jats:italic><\/jats:styled-content>, ugt73b5<\/jats:italic><\/jats:styled-content> and ugt73b3 ugt73b5<\/jats:italic> T\u2010DNA<\/jats:styled-content> insertion mutants exhibited an accumulation of reactive oxygen species (ROS<\/jats:styled-content>), an enhanced cell death during the HR<\/jats:styled-content> to Pst\u2010AvrRpm1<\/jats:italic><\/jats:styled-content>, whereas glutathione levels increased in the single mutants. In silico<\/jats:italic> analyses indicate that UGT73B3<\/jats:italic><\/jats:styled-content> and UGT73B5<\/jats:italic><\/jats:styled-content> belong to the early salicylic acid (SA<\/jats:styled-content>)<\/jats:italic>\u2010induced<\/jats:italic> genes whose pathogen\u2010induced expression is co\u2010regulated with genes related to cellular redox homeostasis and general detoxification. Analyses of metabolic alterations in ugt<\/jats:italic><\/jats:styled-content> mutants reveal modification of SA<\/jats:styled-content> and scopoletin contents which correlate with redox perturbation, and indicate quantitative modifications in the pattern of tryptophan\u2010derived SM<\/jats:styled-content> accumulation after Pst\u2010AvrRpm1<\/jats:italic><\/jats:styled-content> inoculation. Our data suggest that UGT73B3<\/jats:roman><\/jats:styled-content> and UGT73B5<\/jats:roman><\/jats:styled-content> participate in regulation of redox status and general detoxification of ROS<\/jats:styled-content>\u2010reactive SMs<\/jats:styled-content> during the HR<\/jats:styled-content> to Pst\u2010AvrRpm1<\/jats:italic><\/jats:styled-content>, and that decreased resistance to Pst\u2010AvrRpm1<\/jats:italic><\/jats:styled-content> in ugt<\/jats:italic><\/jats:styled-content> mutants is tightly linked to redox perturbation.<\/jats:p>","DOI":"10.1111\/pce.12221","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T08:22:56Z","timestamp":1381998176000},"page":"1114-1129","source":"Crossref","is-referenced-by-count":74,"title":["The secondary metabolism glycosyltransferases UGT73B3<\/scp><\/scp> and UGT73B5<\/scp><\/scp> are components of redox status in resistance of A<\/scp>rabidopsis to P<\/scp><\/i>seudomonas syringae<\/i> pv. tomato<\/i>"],"prefix":"10.1111","volume":"37","author":[{"given":"CLARA","family":"SIMON","sequence":"first","affiliation":[{"name":"Institut de Biologie des Plantes CNRS\u2010Universit\u00e9 Paris\u2010Sud 11 UMR 8618, B\u00e2timent 630 91405 Orsay Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MATHILDE","family":"LANGLOIS\u2010MEURINNE","sequence":"additional","affiliation":[{"name":"Institut de Biologie des Plantes CNRS\u2010Universit\u00e9 Paris\u2010Sud 11 UMR 8618, B\u00e2timent 630 91405 Orsay Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAURE","family":"DIDIERLAURENT","sequence":"additional","affiliation":[{"name":"Institut de Biologie des Plantes CNRS\u2010Universit\u00e9 Paris\u2010Sud 11 UMR 8618, B\u00e2timent 630 91405 Orsay Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEJIR","family":"CHAOUCH","sequence":"additional","affiliation":[{"name":"Institut de Biologie des Plantes 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