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Based upon metabolomic changes in oat (<jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>vena sativa<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.), we have defined key processes involved in drought tolerance. During a time course of increasing water deficit, metabolites from leaf samples were profiled using direct infusion\u2013electrospray mass spectroscopy (<jats:styled-content style=\"fixed-case\">DI\u2010ESI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) and high\u2010performance liquid chromatography (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">ESI\u2010MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and analysed using principal component analysis (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) and discriminant function analysis (<jats:styled-content style=\"fixed-case\">DFA<\/jats:styled-content>). The involvement of metabolite pathways was confirmed through targeted assays of key metabolites and physiological experiments. We demonstrate an early accumulation of salicylic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) influencing stomatal opening, photorespiration and antioxidant defences before any change in the relative water content. These changes are likely to maintain plant water status, with any photoinhibitory effect being counteracted by an efficient antioxidant capacity, thereby representing an integrated mechanism of drought tolerance in oats. We also discuss these changes in relation to those engaged at later points, consequence of the different water status in susceptible and resistant genotypes.<\/jats:p>","DOI":"10.1111\/pce.12501","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T09:24:42Z","timestamp":1419326682000},"page":"1434-1452","source":"Crossref","is-referenced-by-count":83,"title":["A metabolomic study in oats (<scp><i>A<\/i><\/scp><i>vena sativa<\/i>) highlights a drought tolerance mechanism based upon salicylate signalling pathways and the modulation of carbon, antioxidant and photo\u2010oxidative metabolism"],"prefix":"10.1111","volume":"38","author":[{"given":"JAVIER","family":"S\u00c1NCHEZ\u2010MART\u00cdN","sequence":"first","affiliation":[{"name":"Institute for Sustainable Agriculture CSIC  Apdo. 4084 C\u00f3rdoba 14080 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIM","family":"HEALD","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences University of Aberystwyth  Aberystwyth SY23\u20093DA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALISON","family":"KINGSTON\u2010SMITH","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences University of Aberystwyth  Aberystwyth SY23\u20093DA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANA","family":"WINTERS","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences University of Aberystwyth  Aberystwyth SY23\u20093DA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIEGO","family":"RUBIALES","sequence":"additional","affiliation":[{"name":"Institute for Sustainable Agriculture CSIC  Apdo. 4084 C\u00f3rdoba 14080 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARILUZ","family":"SANZ","sequence":"additional","affiliation":[{"name":"Institute of General Organic Chemistry CSIC  Juan de la Cierva 3 Madrid 28006 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIS A. 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