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In this study, <jats:sup>1<\/jats:sup>H nuclear magnetic resonance (NMR)\u2010based metabolomics along with liquid chromatography and mass spectrometry were used to explore the chemical responses of the susceptible \u2018Williams\u2019 and the resistant \u2018Khai Thong Ruang\u2019 <jats:italic>Musa<\/jats:italic> varieties to the ascomycete fungus <jats:italic>Mycosphaerella fijiensis<\/jats:italic>, the agent of the black leaf Sigatoka disease. Principal component analysis discriminated strongly between infected and non\u2010infected plant tissue, mainly because of specialized metabolism induced in response to the fungus. Phenylphenalenones are among the major induced compounds, and the resistance level of the plants was correlated with the progress of the disease. However, a virulent strain of <jats:italic>M.\u2009fijiensis<\/jats:italic> was able to overcome plant resistance by converting phenylphenalenones to sulfate conjugates. Here, we report the first metabolic detoxification of fungitoxic phenylphenalenones to evade the chemical defence of <jats:italic>Musa<\/jats:italic> plants.<\/jats:p>","DOI":"10.1111\/pce.12630","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T06:31:14Z","timestamp":1440052274000},"page":"492-513","source":"Crossref","is-referenced-by-count":36,"title":["Phenylphenalenones protect banana plants from infection by <i>Mycosphaerella fijiensis<\/i> and are deactivated by metabolic conversion"],"prefix":"10.1111","volume":"39","author":[{"given":"William","family":"Hidalgo","sequence":"first","affiliation":[{"name":"Max\u2010Planck Institut f\u00fcr Chemische \u00d6kologie, Beutenberg Campus  Hans\u2010Kn\u00f6ll\u2010Strasse 8 Jena 07745 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jima N.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Max\u2010Planck Institut f\u00fcr Chemische \u00d6kologie, Beutenberg Campus  Hans\u2010Kn\u00f6ll\u2010Strasse 8 Jena 07745 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya C.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Max\u2010Planck Institut f\u00fcr Chemische \u00d6kologie, Beutenberg Campus  Hans\u2010Kn\u00f6ll\u2010Strasse 8 Jena 07745 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ot\u00e1lvaro","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad de Antioquia  Calle 67# 53\u2010108 Medell\u00edn A.A. 1226 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schneider","sequence":"additional","affiliation":[{"name":"Max\u2010Planck Institut f\u00fcr Chemische \u00d6kologie, Beutenberg Campus  Hans\u2010Kn\u00f6ll\u2010Strasse 8 Jena 07745 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1051\/fruits:2008030"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf902069f"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111930"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-97-9-1112"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00269897"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3430-3_5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1770"},{"key":"e_1_2_6_9_1","volume-title":"Global Evaluation of Musa Germplasm for Resistance to Fusarium Wilt, Mycosphaerella Leaf Spot Diseases and Nematodes: In\u2010depth Evaluation","author":"Carlier J.","year":"2002"},{"key":"e_1_2_6_10_1","first-page":"37","volume-title":"Diseases of Banana, Abac\u00e1 and Enset","author":"Carlier J.","year":"2000"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-2194(02)00121-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300631"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01154-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.010436"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-19-1062"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(1998100)54:2<157::AID-PS799>3.0.CO;2-Y"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3418"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1163\/15685411-00002788"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2812"},{"key":"e_1_2_6_20_1","first-page":"447","article-title":"Comparative analysis of the in vitro and in planta secretomes from Mycosphaerella fijiensis isolates","volume":"119","author":"Escobar L.","year":"2015","journal-title":"British Mycological Society"},{"key":"e_1_2_6_21_1","first-page":"508","article-title":"Control of black Sigatoka disease: challenges and prospects","volume":"6","author":"Etebu E.","year":"2011","journal-title":"African Journal of Agricultural Research"},{"key":"e_1_2_6_22_1","unstructured":"FAO(2014) Banana market review and banana statistic 2012\u20102013.Intergovernmental group on bananas and tropical fruits pp.39."},{"key":"e_1_2_6_23_1","unstructured":"FAO(2015)http:\/\/www.statista.com\/statistics\/264001\/worldwide\u2010production\u2010of\u2010fruit\u2010by\u2010variety\/accessed June 2015."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar0402863"},{"key":"e_1_2_6_25_1","first-page":"110","volume-title":"Banana and Plantain Breeding Strategies. 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