{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:32:30Z","timestamp":1787765550160,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Methusalem","award":["08M03VGRJ"],"award-info":[{"award-number":["08M03VGRJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plant Cell &amp;amp; Environment"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cadmium (Cd) exposure can disturb the homeostasis of essential elements. In\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    , Cd induces a squamosa promoter binding protein\u2010like 7 (SPL7)\u2010dependent Cu deficiency response. We investigated how Cd induces a Cu deficiency response. The Cu deficiency response consists of the active SPL7 transcription factor binding to GTAC motifs in promoters of among others several Cu transporters, a Cu chaperone, and cupro\u2010miRNAs to regulate Cu homeostasis. We demonstrated that the addition of supplemental Cu to Cd\u2010exposed\n                    <jats:italic>A.\u2009thaliana<\/jats:italic>\n                    plants diminished the Cu deficiency response in roots, while it even disappeared in leaves. Exposure of plants to Cd in combination with extra Cu reduced Cd levels in both roots and leaves resulting in an improved cellular oxidative state. Furthermore, we demonstrated a role for phytochelatins (PCs) in the Cd\u2010induced Cu deficiency response, because it was reduced in roots of\n                    <jats:italic>cad1\u20103<\/jats:italic>\n                    mutant plants exposed to Cd. In conclusion, a working mechanism is provided in which it is suggested that Cd increases PC levels that can complex both Cd and Cu. This results in cellular Cu deficiency and subsequently the activation of SPL7 and hence the induction of the Cu deficiency response.\n                  <\/jats:p>","DOI":"10.1111\/pce.12876","type":"journal-article","created":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T18:06:45Z","timestamp":1481479605000},"page":"390-400","source":"Crossref","is-referenced-by-count":39,"title":["Cd\u2010induced Cu deficiency responses in\n                    <i>Arabidopsis thaliana<\/i>\n                    : are phytochelatins involved?"],"prefix":"10.1111","volume":"40","author":[{"given":"Heidi","family":"Gielen","sequence":"first","affiliation":[{"name":"Environmental Biology, Centre for Environmental Sciences Hasselt University  B\u20103590 Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaco","family":"Vangronsveld","sequence":"additional","affiliation":[{"name":"Environmental Biology, Centre for Environmental Sciences Hasselt University  B\u20103590 Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Cuypers","sequence":"additional","affiliation":[{"name":"Environmental Biology, Centre for Environmental Sciences Hasselt University  B\u20103590 Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02601.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112797"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2006.07.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.53.100301.135154"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.123.3.825"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-22081-4_4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7909.2008.00737.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.106.078717"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt00111c"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-016-0830-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.115782"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.107.4.1059"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcv075"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2014.07.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2013.02.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.130294"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.130641"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2008.10.007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2007.09.014"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.12050"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2009.05.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.09.023"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2008.02638.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-015-2443-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.108.060137"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-005-0092-3"}],"container-title":["Plant, Cell &amp; 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