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However, our knowledge of CRYs is predominantly based on model plant Arabidopsis at early growth stage. In this study, we elucidated functions of <jats:italic>CRY1a<\/jats:italic> gene in mature tomato (<jats:styled-content style=\"fixed-case\"><jats:italic>Solanum lycopersicum<\/jats:italic><\/jats:styled-content>) plants by using <jats:italic>cry1a<\/jats:italic> mutants and <jats:italic>CRY1a<\/jats:italic>\u2010overexpressing lines (<jats:italic>OE\u2010CRY1a<\/jats:italic>\u20101 and <jats:italic>OE\u2010CRY1a\u20102<\/jats:italic>). In comparison with wild\u2010type plants, <jats:italic>cry1a<\/jats:italic> mutants are relatively tall, accumulate low biomass, and bear more fruits, whereas <jats:italic>OE\u2010CRY1a<\/jats:italic> plants are short stature, and they not only flower lately but also bear less fruits. RNA\u2010seq, qRT\u2010PCR, and LC\u2010MS\/MS analysis revealed that biosynthesis of gibberellin, cytokinin, and jasmonic acid was down\u2010regulated by <jats:italic>CRY1a<\/jats:italic>. Furthermore, DNA replication was drastically inhibited in leaves of <jats:italic>OE\u2010CRY1a<\/jats:italic> lines, but promoted in <jats:italic>cry1a<\/jats:italic> mutants with concomitant changes in the expression of cell cycle genes<jats:italic>.<\/jats:italic> However, <jats:italic>CRY1a<\/jats:italic> positively regulated levels of soluble sugars, phytofluene, phytoene, lycopene, and \u00df\u2010carotene in the fruits. The results indicate the important role of <jats:italic>CRY1a<\/jats:italic> in plant growth and have implications for molecular interventions of <jats:italic>CRY1a<\/jats:italic> aimed at improving agronomic traits.<\/jats:p>","DOI":"10.1111\/pce.13092","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T23:52:35Z","timestamp":1508370755000},"page":"354-366","source":"Crossref","is-referenced-by-count":63,"title":["Tomato <i>CRY1a<\/i> plays a critical role in the regulation of phytohormone homeostasis, plant development, and carotenoid metabolism in fruits"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-1823","authenticated-orcid":false,"given":"Chao\u2010Chao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Horticulture, Zijingang Campus Zhejiang University  Hangzhou 310058 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