{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:18:42Z","timestamp":1789661922011,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006542","name":"Agencia Antidroga de la Comunidad de Madrid","doi-asserted-by":"publisher","award":["P2013\/ABI\u20102734"],"award-info":[{"award-number":["P2013\/ABI\u20102734"]}],"id":[{"id":"10.13039\/501100006542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stress adaptation and translational regulation was studied using <jats:italic>noxy7<\/jats:italic> (<jats:italic>nonresponding to oxylipins7<\/jats:italic>) from a series of <jats:styled-content style=\"fixed-case\"><jats:italic>Arabidopsis thaliana<\/jats:italic><\/jats:styled-content> mutants. We identified the <jats:italic>noxy7<\/jats:italic> mutation in At1g64790, which encodes a homolog of the yeast translational regulator General Control Nonderepressible1 (GCN1) that activates the GCN2 kinase; GCN2 in turn phosphorylates the \u03b1 subunit of the translation initiation factor eIF2. This regulatory circuit is conserved in yeast and mammals, in which phosphorylated eIF2\u03b1 (P\u2010eIF2\u03b1) facilitates stress adaptation by inhibiting protein synthesis. In phenotypic and <jats:italic>de novo<\/jats:italic> protein synthesis studies with Arabidopsis mutants, we found that NOXY7\/GCN1 and GCN2 mediate P\u2010eIF2\u03b1 formation and adaptation to amino acid deprivation; however, P\u2010eIF2\u03b1 formation is not linked to general protein synthesis arrest. Additional evidence suggested that NOXY7\/GCN1 but not GCN2 regulates adaptation to mitochondrial dysfunction, high boron concentration, and activation of plant immunity to infection by <jats:italic>Pseudomonas syringae<\/jats:italic> pv <jats:italic>tomato<\/jats:italic> (<jats:italic>Pst<\/jats:italic>). In these responses, NOXY7\/GCN1 acts with GCN20 to regulate translation in a noncanonical pathway independently of GCN2 and P\u2010eIF2\u03b1. These results show the lesser functional relevance of GCN2 and P\u2010eIF2\u03b1 in plants relative to other eukaryotes and highlight the prominent role of NOXY7\/GCN1 and GCN20 in regulation of translation and stress adaptation in plants.<\/jats:p>","DOI":"10.1111\/pce.13182","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T20:06:37Z","timestamp":1520021197000},"page":"1438-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Arabidopsis <i>nonresponding to oxylipins<\/i> locus <i>NOXY7<\/i> encodes a yeast GCN1 homolog that mediates noncanonical translation regulation and stress adaptation"],"prefix":"10.1111","volume":"41","author":[{"given":"Yovanny","family":"Izquierdo","sequence":"first","affiliation":[{"name":"Centro Nacional de Biotecnolog\u00eda (CNB\u2010CSIC) Cantoblanco  Madrid E\u201028049 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