{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:21:06Z","timestamp":1790421666272,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007887","name":"Harvard School of Engineering and Applied Sciences","doi-asserted-by":"publisher","award":["VIDI grant 11281"],"award-info":[{"award-number":["VIDI grant 11281"]}],"id":[{"id":"10.13039\/100007887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["269072"],"award-info":[{"award-number":["269072"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Jasmonic acid (JA) regulates plant defenses against necrotrophic pathogens and insect herbivores. Salicylic acid (SA) and abscisic acid (ABA) can antagonize JA\u2010regulated defenses, thereby modulating pathogen or insect resistance. We performed a genome\u2010wide association (GWA) study on natural genetic variation in\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    for the effect of SA and ABA on the JA pathway. We treated 349\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    accessions with methyl JA (MeJA), or a combination of MeJA and either SA or ABA, after which expression of the JA\u2010responsive marker gene\n                    <jats:italic>PLANT DEFENSIN1.2<\/jats:italic>\n                    (\n                    <jats:italic>PDF1.2<\/jats:italic>\n                    ) was quantified as a readout for GWA analysis. Both hormones antagonized MeJA\u2010induced\n                    <jats:italic>PDF1.2<\/jats:italic>\n                    in the majority of the accessions but with a large variation in magnitude. GWA mapping of the SA\u2010 and ABA\u2010affected\n                    <jats:italic>PDF1.2<\/jats:italic>\n                    expression data revealed loci associated with crosstalk.\n                    <jats:italic>GLYI4<\/jats:italic>\n                    (encoding a glyoxalase) and\n                    <jats:italic>ARR11<\/jats:italic>\n                    (encoding an\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    response regulator involved in cytokinin signalling) were confirmed by T\u2010DNA insertion mutant analysis to affect SA\u2013JA crosstalk and resistance against the necrotroph\n                    <jats:italic>Botrytis cinerea<\/jats:italic>\n                    . In addition,\n                    <jats:italic>At1g16310<\/jats:italic>\n                    (encoding a cation efflux family protein) was confirmed to affect ABA\u2013JA crosstalk and susceptibility to\n                    <jats:italic>Mamestra brassicae<\/jats:italic>\n                    herbivory. Collectively, this GWA study identified novel players in JA hormone crosstalk with potential roles in the regulation of pathogen or insect resistance.\n                  <\/jats:p>","DOI":"10.1111\/pce.13357","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T22:45:59Z","timestamp":1527806759000},"page":"2342-2356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Genome\u2010wide association study reveals novel players in defense hormone crosstalk in\n                    <i>Arabidopsis<\/i>"],"prefix":"10.1111","volume":"41","author":[{"given":"Silvia","family":"Proietti","sequence":"first","affiliation":[{"name":"Plant\u2010Microbe Interactions, Department of Biology, Science4Life Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Caarls","sequence":"additional","affiliation":[{"name":"Plant\u2010Microbe Interactions, Department of Biology, Science4Life Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Coolen","sequence":"additional","affiliation":[{"name":"Plant\u2010Microbe Interactions, Department of Biology, Science4Life Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan A.","family":"Van Pelt","sequence":"additional","affiliation":[{"name":"Plant\u2010Microbe Interactions, Department of Biology, Science4Life Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia C.M.","family":"Van Wees","sequence":"additional","affiliation":[{"name":"Plant\u2010Microbe Interactions, Department of Biology, Science4Life Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-4646","authenticated-orcid":false,"given":"Corn\u00e9 M.J.","family":"Pieterse","sequence":"additional","affiliation":[{"name":"Plant\u2010Microbe Interactions, Department of Biology, Science4Life Utrecht University  Utrecht The 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