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In this manuscript, we show that organs from CAF\u20101 deficient plants respond differently to ultraviolet\u2010B (UV\u2010B) radiation than to other genotoxic stresses. For example, CAF\u20101 deficient leaves tolerate better UV\u2010B radiation, showing lower cyclobutane pyrimidine dimer (CPD) accumulation, lower inhibition of cell proliferation, increased cell wall thickness, UV\u2010B absorbing compounds, and ploidy levels, whereas previous data from different groups have shown that CAF\u20101 mutants show shortening of telomeres, loss of 45S rDNA, and increased homologous recombination, phenotypes associated to DNA breaks. Interestingly, CAF\u20101 deficient roots show increased inhibition of primary root elongation, with decreased meristem size due to a higher inhibition of cell proliferation after UV\u2010B exposure. The decrease in root meristem size in CAF\u20101 mutants is a consequence of defects in programmed cell death after UV\u2010B exposure. Together, we provide evidence demonstrating that root and shoot meristematic cells may have distinct protection mechanisms against CPD accumulation by UV\u2010B, which may be linked with different functions of the CAF\u20101 complex in these different organs.<\/jats:p>","DOI":"10.1111\/pce.13596","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:09:18Z","timestamp":1559243358000},"page":"2730-2745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["AtCAF\u20101 mutants show different DNA damage responses after ultraviolet\u2010B than those activated by other genotoxic agents in leaves"],"prefix":"10.1111","volume":"42","author":[{"given":"Evangelina","family":"Mauli\u00f3n","sequence":"first","affiliation":[{"name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Sol","family":"Gomez","sequence":"additional","affiliation":[{"name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Anabel","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-4683","authenticated-orcid":false,"given":"Paula","family":"Casati","sequence":"additional","affiliation":[{"name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.02.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3040.2003.00988.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2005.01548.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.47.1.75"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.113.117473"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.047043"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2010.04249.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.010108"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.00967"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02931.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2017.09.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf053"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ery242"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/sst021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601434"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02599"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.16.00033"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2014.12.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.17.00365"},{"key":"e_1_2_8_21_1","volume-title":"DNA damage","author":"Friedberg E. 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