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However, the defensive mechanisms triggered by stilbene synthase (STS<\/jats:italic>) genes, remain largely unknown. Here, we report the function and molecular mechanism of the stilbene synthase gene VpSTS29\/STS2<\/jats:italic> from Vitis pseudoreticulata<\/jats:italic> in the regulation of plant responses to powdery mildew. Stilbene synthesis occurred mainly in root tips and mesophyll cells of transgenic grapevines via transport through the vascular bundles. Overexpression of VpSTS29\/STS2<\/jats:italic> in Vitis vinifera<\/jats:italic><\/jats:styled-content> increased the abundance of STSs in mesophyll tissue and resulted in the accumulation of biologically active resveratrol derivatives at the invasion site. Similarly, expression of VpSTS29\/STS2<\/jats:italic> in Arabidopsis<\/jats:italic> increased resistance to Golovinomyces cichoracearum<\/jats:italic>. The VpSTS29\/STS2<\/jats:italic>\u2010expressing Arabidopsis<\/jats:italic> lines showed increased piceid accumulation together with more local hypersensitive reactions, inhibition of mycelial growth, and a reduced incidence of pathogens. Transcriptome profiling analyses demonstrated that VpSTS29\/STS2<\/jats:italic>\u2010induced defences led to reprograming of global gene expression and activation of salicylic acid (SA) signalling, thus increasing expression of WRKY\u2010MYB transcription factors and other defence response genes. We propose a model for resveratrol\u2010mediated coordination of defence responses in which SA participates in a positive feedback loop.<\/jats:p>","DOI":"10.1111\/pce.13600","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T07:11:42Z","timestamp":1563261102000},"page":"2979-2998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["VpSTS29\/STS2<\/i> enhances fungal tolerance in grapevine through a positive feedback loop"],"prefix":"10.1111","volume":"42","author":[{"given":"Weirong","family":"Xu","sequence":"first","affiliation":[{"name":"College of Horticulture Northwest A&F University Yangling People's Republic of China"},{"name":"Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture Northwest A&F University Yangling People's Republic of China"},{"name":"State Key Laboratory of Crop Stress Biology in Arid Areas Northwest A&F University Yangling People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuli","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Horticulture Northwest A&F University Yangling People's Republic of China"},{"name":"Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture Northwest A&F University Yangling People's Republic of China"},{"name":"State Key Laboratory of Crop Stress Biology in Arid Areas Northwest A&F University Yangling People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Horticulture Northwest A&F University Yangling People's Republic of China"},{"name":"Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture Northwest A&F University Yangling People's Republic of 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