{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:52:41Z","timestamp":1790232761539,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005147","name":"Applied Basic Research Key Project of Yunnan","doi-asserted-by":"publisher","award":["2017FB026"],"award-info":[{"award-number":["2017FB026"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Iron (Fe) is an essential micronutrient for plant growth development and plays a key role in regulating numerous cellular processes. In rice, OsHRZ1, an Fe\u2010binding ubiquitin ligase, is a putative sensor of Fe homeostasis that negatively regulates iron acquisition. Despite its apparent importance, only a single basic\u2010Helix\u2013Loop\u2013Helix (bHLH) transcription factor, OsPRI1, has been identified as a direct target of OsHRZ1. In this study, we identified and functionally characterized OsPRI2 and OsPRI3, two paralogs of OsPRI1, observing that they directly interact with OsHRZ1. Additional analyses suggested that OsHRZ1 promotes the degradation of OsPRI2 and OsPRI3. The translocation of Fe from roots to shoots was impaired in plants with loss\u2010of\u2010function mutations in\n                    <jats:italic>OsPRI2<\/jats:italic>\n                    or\n                    <jats:italic>OsPRI3<\/jats:italic>\n                    , causing the downregulation of Fe\u2010deficiency\u2010responsive genes. In contrast, overexpression of\n                    <jats:italic>OsPRI2<\/jats:italic>\n                    and\n                    <jats:italic>OsPRI3<\/jats:italic>\n                    promotes Fe accumulation and activates the expression of Fe\u2010deficiency\u2010responsive genes. We also provide evidence that OsPRI2 and OsPRI3 bind to the promoters of\n                    <jats:italic>OsIRO2<\/jats:italic>\n                    and\n                    <jats:italic>OsIRO3<\/jats:italic>\n                    , two key regulators of Fe homeostasis. Moreover, OsPRI2 and OsPRI3 directly induce expression of the metal\u2010nicotianamine transporter,\n                    <jats:italic>OsYSL2<\/jats:italic>\n                    , by associating with the promoter in response to Fe deficiency. Our results provide insights into the complex network regulating Fe homeostasis in rice.\n                  <\/jats:p>","DOI":"10.1111\/pce.13655","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T09:31:44Z","timestamp":1572600704000},"page":"261-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["<scp>\n                      <i>Oryza sativa<\/i>\n                    <\/scp>\n                    POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis"],"prefix":"10.1111","volume":"43","author":[{"given":"Huimin","family":"Zhang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, The Innovative Academy of Seed Design Chinese Academy of Sciences  Kunming Yunnan 650223 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, The Innovative Academy of Seed Design Chinese Academy of Sciences  Kunming Yunnan 650223 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Pu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, The Innovative Academy of Seed Design Chinese Academy of Sciences  Kunming Yunnan 650223 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, The Innovative Academy of Seed Design Chinese Academy of Sciences  Kunming Yunnan 650223 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-4043","authenticated-orcid":false,"given":"Gang","family":"Liang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, The Innovative Academy of Seed Design Chinese Academy of Sciences  Kunming Yunnan 650223 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diqiu","family":"Yu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, The Innovative Academy of Seed Design Chinese Academy of Sciences  Kunming Yunnan 650223 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