{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:34:06Z","timestamp":1790678046665,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rapid reconfigurations of interconnected phytohormone signalling networks allow plants to tune their physiology to constantly varying ecological conditions. During insect herbivory, most of the induced changes in defence\u2010related leaf metabolites are controlled by jasmonate (JA) signalling, which, in the wild tobacco\n                    <jats:italic>Nicotiana attenuata<\/jats:italic>\n                    , recruits MYB8, a transcription factor controlling the accumulation of phenolic\u2010polyamine conjugates (phenolamides). In this and other plant species, herbivory also locally triggers ethylene (ET) production but the outcome of the JA\u2010ET cross\u2010talk at the level of secondary metabolism regulation has remained only superficially investigated. Here, we analysed local and systemic herbivory\u2010induced changes by mass spectrometry\u2010based metabolomics in leaves of transgenic plants impaired in JA, ET and MYB8 signalling. Parsing deregulations in this factorial data\u2010set identified a network of JA\/MYB8\u2010dependent phenolamides for which impairment of ET signalling attenuated their accumulation only in locally damaged leaves. Further experiments revealed that ET, albeit biochemically interrelated to polyamine metabolism via the intermediate\n                    <jats:italic>S<\/jats:italic>\n                    \u2010adenosylmethionine, does not alter the free polyamine levels, but instead significantly modulates phenolamide levels with marginal modulations of transcript levels. The work identifies ET as a local modulator of phenolamide accumulations and provides a metabolomics data\u2010platform with which to mine associations among herbivory\u2010induced signalling and specialized metabolites in\n                    <jats:italic>N. attenuata<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/pce.13955","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T15:13:22Z","timestamp":1605885202000},"page":"964-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Ethylene is a local modulator of jasmonate\u2010dependent phenolamide accumulation during\n                    <i>Manduca sexta<\/i>\n                    herbivory in\n                    <scp>\n                      <i>Nicotiana attenuata<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-3865","authenticated-orcid":false,"given":"Florent","family":"Figon","sequence":"first","affiliation":[{"name":"Department of Molecular Ecology Max Planck Institute for Chemical Ecology  Jena Germany"},{"name":"Master BioSciences, ENS de Lyon, UCB Lyon 1 Universit\u00e9 de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-2974","authenticated-orcid":false,"given":"Ian T.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Molecular Ecology Max Planck Institute for Chemical Ecology  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-6417","authenticated-orcid":false,"given":"Emmanuel","family":"Gaquerel","sequence":"additional","affiliation":[{"name":"Department of Molecular Ecology Max Planck Institute for Chemical Ecology  Jena Germany"},{"name":"Institut de Biologie Mol\u00e9culaire des Plantes du CNRS Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12640"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.08.003"},{"key":"e_1_2_7_4_1","first-page":"2371","article-title":"Ethylene: Traffic controller on hormonal crossroads to defense","volume":"169","author":"Broekgaarden C.","year":"2015","journal-title":"Plant 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