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Formaldehyde and UV\u2010B irradiation cause DNA damage and affect genome stability, growth\u00a0and development, but the interplay between these two genotoxic factors is poorly understood in plants. We show that <jats:italic>Arabidopsis adh2\/gsnor1<\/jats:italic> mutant, which lacks alcohol dehydrogenase 2\/<jats:italic>S<\/jats:italic>\u2010nitrosoglutathione reductase 1 (ADH2\/GSNOR1), are hypersensitive to low fluence UV\u2010B irradiation or UV\u2010B irradiation\u2010mimetic chemicals. Although the ADH2\/GSNOR1 enzyme can act on different substrates, notably on <jats:italic>S<\/jats:italic>\u2010hydroxymethylglutathione (HMG) and <jats:italic>S<\/jats:italic>\u2010nitrosoglutathione (GSNO), our study provides several lines of evidence that the sensitivity of <jats:italic>gsnor1<\/jats:italic> to UV\u2010B is caused mainly by UV\u2010B\u2010induced formaldehyde accumulation rather than other factors such as alteration of the GSNO concentration. Our results demonstrate an interplay between formaldehyde and UV\u2010B that exacerbates genome instability, leading to severe DNA damage and impaired growth and development in <jats:italic>Arabidopsis<\/jats:italic>, and show that ADH2\/GSNOR1 is a key player in combating these effects.<\/jats:p>","DOI":"10.1111\/pce.14249","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T14:28:21Z","timestamp":1639751301000},"page":"378-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ADH2\/GSNOR1 is a key player in limiting genotoxic damage mediated by formaldehyde and UV\u2010B in <i>Arabidopsis<\/i>"],"prefix":"10.1111","volume":"45","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Life Sciences Capital Normal University Beijing 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