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Here, we show that moderate drought stress enhances the susceptibility of <jats:italic>Arabidopsis thaliana<\/jats:italic> to <jats:italic>Pseudomonas syringae<\/jats:italic> pv. <jats:italic>tomato<\/jats:italic> DC3000. Using transcriptome meta\u2010analysis, we found that drought and bacterial stress antagonistically modulate a large set of genes predominantly involved in salicylic acid (SA) and abscisic acid (ABA) signalling networks. We identified that the levels of SA and ABA are dynamically regulated during the course of stress. Importantly, under combined stress, drought through the ABA pathway downregulates the induction of Calmodulin\u2010binding Protein 60\u2009g (CBP60g) and Systemic Acquired Resistance Deficient 1 (SARD1), two transcription factors crucial for SA production upon bacterial infection. We also identified an important role of NPR1\u2010LIKE PROTEIN 3 and 4 (NPR3\/4) transcriptional repressors in the drought\u2010mediated negative regulation of <jats:italic>CBP60g\/SARD1<\/jats:italic> expression. Using a genetic approach, we show that <jats:italic>CBP60g\/SARD1<\/jats:italic> expression is the key determinant of plant defence against bacterial pathogens under combined stress. Thus, these transcription factors act as critical nodes for the crosstalk between drought and bacterial stress signalling under combined stress in plants.<\/jats:p>","DOI":"10.1111\/pce.14275","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T08:42:59Z","timestamp":1643704979000},"page":"1127-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Drought attenuates plant defence against bacterial pathogens by suppressing the expression of <i>CBP60g<\/i>\/<i>SARD1<\/i> during combined stress"],"prefix":"10.1111","volume":"45","author":[{"given":"Aanchal","family":"Choudhary","sequence":"first","affiliation":[{"name":"National Institute of Plant Genome Research, Aruna Asaf Ali Marg  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-1659","authenticated-orcid":false,"given":"Muthappa","family":"Senthil\u2010Kumar","sequence":"additional","affiliation":[{"name":"National Institute of Plant Genome Research, Aruna Asaf Ali Marg  New Delhi 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