{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:31:48Z","timestamp":1785328308442,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Salicylic acid (SA) is a crucial hormone involved in plant immunity. Rice (<jats:italic>Oryza sativa<\/jats:italic>) maintains high SA levels that are not induced by pathogens. However, the roles of SA in rice immunity and yield remain largely unknown. Here, we identified SA 5\u2010hydroxylases 1 (OsS5H1) and 2 (OsS5H2) as the primary enzymes engaged in catalysing SA to 2,5\u2010dihydroxybenzoic acid (2,5\u2010DHBA) in rice. SA levels were significantly increased in the <jats:italic>oss5h<\/jats:italic> mutants, while they were dramatically decreased in the <jats:italic>OsS5H1<\/jats:italic> and <jats:italic>OsS5H2<\/jats:italic> overexpression lines. The mutants were resistant, whereas the overexpression lines were susceptible to <jats:italic>Pyricularia oryzae<\/jats:italic> and <jats:italic>Xanthomonas oryzae<\/jats:italic> pv. <jats:italic>Oryzae<\/jats:italic>. Moreover, the pathogen\u2010associated molecular patterns\u2010triggered immunity\u00a0responses, including reactive oxygen species\u00a0burst and callose deposition, were enhanced in all the mutants and compromised in the overexpression lines. Quantification of the agronomic traits of the <jats:italic>oss5h<\/jats:italic> mutants grown in the paddy fields demonstrated that the grain number per panicle was decreased as the SA levels increased; however, the tiller number and grain size were enhanced, resulting in no significant yield penalty. Collectively, we reveal that mildly increasing SA content in rice can confer broad\u2010spectrum resistance without yield penalty and put new insights into the roles of SA in immunity and growth.<\/jats:p>","DOI":"10.1111\/pce.14328","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T15:25:25Z","timestamp":1649431525000},"page":"2211-2225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Disruption of the primary salicylic acid hydroxylases in rice enhances broad\u2010spectrum resistance against pathogens"],"prefix":"10.1111","volume":"45","author":[{"given":"Yanjun","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants, College of Chemistry and Life Sciences Zhejiang Normal University Jinhua Zhejiang 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