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By using forward genetic screening from a rice ethyl methanesulfonate mutant library, we obtained a mutant showing specifically high sensitivity to Al. Through MutMap analysis followed by a complementation test, we identified the causal gene, <jats:italic>Al\u2010related Protein Kinase<\/jats:italic> (<jats:italic>ArPK<\/jats:italic>) for Al\u2010sensitivity. <jats:italic>ArPK<\/jats:italic> expression was induced by a relatively longer exposure to high Al concentration in the roots. The result of RNA\u2010sequencing indicated the functional disorder in arginine metabolism pathway with downregulation of <jats:italic>N<\/jats:italic>\u2010<jats:italic>acetylornithine deacetylase<\/jats:italic> (<jats:italic>NAOD<\/jats:italic>) expression and upregulation of <jats:italic>Ornithine decarboxylase1<\/jats:italic> (<jats:italic>ODC1<\/jats:italic>) expression in <jats:italic>arpk<\/jats:italic> mutant. Al specifically and rapidly upregulated <jats:italic>ODC1<\/jats:italic> expression and causes overaccumulation of putrescine (Put), whereas the ODC inhibitor difluoromethylornithine reverted Al\u2010sensitive phenotype of <jats:italic>arpk<\/jats:italic>, suggesting that overaccumulation of endogenous Put might be harmful for root growth, and that <jats:italic>ArPK<\/jats:italic> seems to act as an endogenous inhibitor of ODC1 action to maintain suitable endogenous Put level under Al treatment. Overall, we identified <jats:italic>ArPK<\/jats:italic> and its putative repressive role in controlling a novel ODC\u2010dependent Put biosynthesis pathway specifically affecting rice Al resistance, thus enriching the fundamental understanding of plant Al resistance.<\/jats:p>","DOI":"10.1111\/pce.14371","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:04:50Z","timestamp":1654247090000},"page":"2520-2532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A novel kinase subverts aluminium resistance by boosting ornithine decarboxylase\u2010dependent putrescine biosynthesis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-1782","authenticated-orcid":false,"given":"Xiang P.","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences Zhejiang University 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