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Recent studies uncovered its molecular function, but its physiological function in the systemic Fe response is not fully understood. To explore the physiological function of FEP1 in iron homoeostasis, we performed a transcriptome analysis using the <jats:italic>FEP1<\/jats:italic> loss\u2010of\u2010function mutant <jats:italic>fep1\u20101<\/jats:italic> and a transgenic line with oestrogen\u2010inducible expression of <jats:italic>FEP1<\/jats:italic>. We determined that FEP1 specifically regulates several iron deficiency\u2010responsive genes, indicating that FEP1 participates in iron translocation rather than iron uptake in roots. The iron concentration in xylem sap under iron\u2010deficient conditions was lower in the <jats:italic>fep1\u20101<\/jats:italic> mutant and higher in <jats:italic>FEP1<\/jats:italic>\u2010induced transgenic plants compared with the wild type (WT). Perls staining revealed a greater accumulation of iron in the cortex of <jats:italic>fep1\u20101<\/jats:italic> roots than in the WT root cortex, although total iron levels in roots were comparable in the two genotypes. Moreover, the <jats:italic>fep1\u20101<\/jats:italic> mutation partially suppressed the iron overaccumulation phenotype in the leaves of the <jats:italic>oligopeptide transporter3\u20102<\/jats:italic> (<jats:italic>opt3\u20102<\/jats:italic>) mutant. These data suggest that FEP1 plays a pivotal role in iron movement and in maintaining the iron quota in vascular tissues in <jats:italic>Arabidopsis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pce.14424","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T08:39:51Z","timestamp":1661157591000},"page":"3322-3337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["FE UPTAKE\u2010INDUCING PEPTIDE1 maintains Fe translocation by controlling Fe deficiency response genes in the vascular tissue of <i>Arabidopsis<\/i>"],"prefix":"10.1111","volume":"45","author":[{"given":"Satoshi","family":"Okada","sequence":"first","affiliation":[{"name":"Group of Environmental Stress Response Systems, Institute of Plant Science and Resources Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui 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