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Histone acetylation is an important epigenetic modification, however, its relationship with cassava disease resistance remains unclear. Here, we identified 10 histone acetyltransferases in cassava and found that the transcript of\n                    <jats:italic>MeHAM1<\/jats:italic>\n                    showed the highest induction to CBB. Functional analysis showed that MeHAM1 positively regulated disease resistance to CBB through modulation of salicylic acid (SA) accumulation. Further investigation revealed that MeHAM1 directly activated SA biosynthetic genes\u2019 expression via promoting lysine 9 of histone 3 (H3K9) acetylation and lysine 5 of histone 4 (H4K5) acetylation of these genes. In addition, molecular chaperone MeDNAJA2 physically interacted with MeHAM1, and MeDNAJA2 also regulated plant immune responses and SA biosynthetic genes. In conclusion, this study illustrates that MeHAM1 and MeDNAJA2 confer immune responses through transcriptional programming of SA biosynthetic genes via histone acetylation. The MeHAM1 &amp; MeDNAJA2\u2010SA biosynthesis module not only constructs the direct relationship between histone acetylation and cassava disease resistance, but also provides gene network with potential value for genetic improvement of cassava disease resistance.\n                  <\/jats:p>","DOI":"10.1111\/pce.14501","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T07:20:54Z","timestamp":1669879254000},"page":"635-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Histone acetyltransferase HAM1 interacts with molecular chaperone DNAJA2 and confers immune responses through salicylic acid biosynthetic genes in cassava"],"prefix":"10.1111","volume":"46","author":[{"given":"Huiping","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Key Laboratory for Sustainable Utilization of Tropical Bioresources (Provincial Ministry Building State Key Laboratory Breeding Base), Sanya Nanfan Research Institute\u2010College of Tropical Crops, Collaborative Innovation Center of Nanfan and High\u2010Efficiency Tropical Agriculture Hainan University Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Ge","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Key Laboratory for Sustainable Utilization of Tropical Bioresources (Provincial Ministry Building State Key Laboratory Breeding Base), Sanya Nanfan Research Institute\u2010College of Tropical Crops, Collaborative Innovation Center of Nanfan and High\u2010Efficiency Tropical Agriculture Hainan University Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biotechnology of Salt Tolerant 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