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We report here that SAR triggered by exogenous NHP treatment requires the function of the transcription factors TGA2\/5\/6 in addition to NPR1, and is further positively affected by TGA1\/4. Consistently, a <jats:italic>tga2\/5\/6<\/jats:italic> triple knockout mutant is fully impaired in NHP\u2010induced SAR gene expression, while a <jats:italic>tga1\/4<\/jats:italic> double mutant shows an attenuated, partial transcriptional response to NHP. Moreover, <jats:italic>tga2\/5\/6<\/jats:italic> and <jats:italic>tga1\/4<\/jats:italic> exhibited fully and strongly impaired pathogen\u2010triggered SAR, respectively, while SA\u2010induced resistance was more moderately compromised in both lines. At the same time, <jats:italic>tga2\/5\/6<\/jats:italic> was not and <jats:italic>tga1\/4<\/jats:italic> only partially impaired in the accumulation of NHP and SA at sites of bacterial attack. Strikingly, SAR gene expression in the systemic tissue induced by local bacterial inoculation or locally applied NHP fully required functional TGA2\/5\/6 and largely depended on TGA1\/4 factors. The systemic accumulation of NHP and SA was attenuated but not abolished in the SAR\u2010compromised and transcriptionally blocked <jats:italic>tga<\/jats:italic> mutants, suggesting their transport from inoculated to systemic tissue. Our results indicate the existence of a critical TGA\u2010 and NPR1\u2010dependent transcriptional module that mediates the induction of SAR and systemic defence gene expression by NHP.<\/jats:p>","DOI":"10.1111\/pce.14572","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T12:59:44Z","timestamp":1676465984000},"page":"1900-1920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["N\u2010hydroxypipecolic acid induces systemic acquired resistance and transcriptional reprogramming via TGA transcription factors"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-0358","authenticated-orcid":false,"given":"Ipek","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Biology, Institute for Molecular Ecophysiology of Plants Heinrich Heine University D\u00fcsseldorf 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