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Phytochromes (<jats:italic>PHY<\/jats:italic>) and cryptochromes (<jats:italic>CRY<\/jats:italic>) perceive the red (R)\/far\u2010red (FR)\u00a0and blue light\u00a0respectively, thus playing a fundamental role in regulating plant growth and development. PHYO and PHYP from conifers are the equivalents of PHYA\/PHYC\u00a0and PHYB in angiosperms, respectively. Norway spruce shows an adaptive latitudinal cline for shade (low R:FR or FR\u2010enriched light) tolerance and requirement of FR light for its growth. We analyzed the exome capture data that included a uniquely large data set of 1654 Norway spruce trees sampled across many latitudes in Sweden to capture the natural clines for photoperiod and FR light exposure during the growth season. Statistically significant clinal variation was detected in allele and genotype frequencies of missense mutations in coding regions belonging to well\u2010defined functional domains of <jats:italic>PHYO<\/jats:italic> (PAS\u2010B),\u00a0<jats:italic>PHYP2<\/jats:italic> (PAS\u00a0fold\u20102), <jats:italic>CRY1<\/jats:italic> (CCT1)\u00a0and <jats:italic>CRY2<\/jats:italic> (CCT2)\u00a0that strongly correlates with the latitudinal gradient in response to variable light quality in Norway spruce. The missense SNP in <jats:italic>PHYO<\/jats:italic> resulting in Asn835Ser, displayed the steepest cline among all other polymorphisms. We propose that these variations in the photoreceptors represent signs of local adaptation to light quality.<\/jats:p>","DOI":"10.1111\/pce.14638","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T05:37:16Z","timestamp":1686289036000},"page":"2391-2400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinal variation in <i>PHY<\/i> (PAS domain) and <i>CRY<\/i> (CCT domain)\u2014Signs of local adaptation to light quality in Norway spruce"],"prefix":"10.1111","volume":"46","author":[{"given":"Sonali Sachin","family":"Ranade","sequence":"first","affiliation":[{"name":"Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre Swedish University of Agricultural Sciences Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-6708","authenticated-orcid":false,"given":"Mar\u00eda 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