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In <jats:italic>Neofusicoccum parvum<\/jats:italic> Bt\u201067, plant\u2010derived ferulic acid makes the fungus release Fusicoccin aglycone triggering plant cell death. Now, we show that the absence of ferulic acid lets the fungus secrete 4\u2010hydroxyphenylacetic acid (4\u2010HPA), mimicking the effect of auxins on grapevine defence and facilitating fungal spread. Using <jats:italic>Vitis<\/jats:italic> suspension cells, we dissected the mode of action of 4\u2010HPA during defence triggered by the bacterial cell\u2010death elicitor, harpin. Early responses (cytoskeletal remodelling and calcium influx) are inhibited, as well as the expression of <jats:italic>Stilbene Synthase 27<\/jats:italic> and phytoalexin accumulation. In contrast to other auxins, 4\u2010HPA quells transcripts for the auxin conjugating GRETCHEN HAGEN 3. We suggest that 4\u2010HPA is a key component of the endophytic phase of <jats:italic>N. parvum<\/jats:italic> Bt\u201067 preventing host cell death. Therefore, our study paves the way to understand how GTDs regulate their latent phase for successful colonisation, before turning necrotrophic and killing the vines.<\/jats:p>","DOI":"10.1111\/pce.14670","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T12:29:23Z","timestamp":1689078563000},"page":"3575-3591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The fungal metabolite 4\u2010hydroxyphenylacetic acid from <i>Neofusicoccum parvum<\/i> modulates defence responses in grapevine"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-8678","authenticated-orcid":false,"given":"Noemi","family":"Flubacher","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology Joseph Gottlieb K\u00f6lreuter Institute of Plant Science, Karlsruhe Institute of Technology Karlsruhe 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